ArticleNutrients2023
Plant Protein but Not Animal Protein Consumption Is Associated with Frailty through Plasma Metabolites.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Network Analysis of Food Intake Patterns and Frailty Dimensions in Chinese Older Adults: A National Cross-Sectional Study.Nutrients · 2026Article
- Association of dietary energy and protein intake with frailty among patients with cirrhosis and implications for nursing practice.International journal of nursing sciences · 2026Article
- Development of a prediction model for identifying older adults with low protein using a simple food intake questionnaire.Journal of nutritional science · 2026Article
- Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study.BMC medicine · 2025Article
- Association of Dietary Choline Intake With Incidence of Frailty: A Nationwide Prospective Cohort Study From China.Journal of cachexia, sarcopenia and muscle · 2025Article
- Plant and Animal Protein Intake and Transitions From Multimorbidity to Frailty and Mortality in Older Adults.Journal of cachexia, sarcopenia and muscle · 2025Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
There is evidence that the association of protein intake and frailty may depend on the source of dietary protein. The mechanism underlying this association is not clear. In this study, we explore circulating metabolites as mediators of the relationship between dietary protein and of frailty in participants of the Baltimore Longitudinal Study of Aging (BLSA). Cross-sectional analyses in 735 BLSA participants of associations between plant and animal protein intake and frailty. Usual protein intake from plant and animal sources were estimated with a Food Frequency Questionnaire (FFQ) and frailty was assessed with a 44-item Frailty Index (FI). Compared with the lowest quartile, higher quartiles of plant, but not animal, protein were associated with lower FI. Twenty-five plasma metabolites were associated with plant protein intake; of these, fifteen, including phosphatidylcholines, cholesterol esters, sphingomyelins, and indole metabolites, mediated the association between plant protein intake and FI. The protective association between plant protein consumption and FI is mediated by lower abundance of lipid metabolites and higher abundance of tryptophan-related metabolites.
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Registered trials
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