Evidence map›Paper›PMID 37836472›Full record

Trial reportNutrients2023

Aronia in the Type 2 Diabetes Treatment Regimen.

Christine B Christiansen, Per B Jeppesen, Kjeld Hermansen, Søren Gregersen

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impact of a Chokeberry (Nutrients · 2025
    Pooled it
  3. Trial
  4. Trial
  5. A Review ofFoods (Basel, Switzerland) · 2026
    Review
  6. Review
  7. Enzymolysis-Driven Development of a Gut-TargetedFoods (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christine B ChristiansenDepartment of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.ORCID 0000-0001-6381-5360
Per B JeppesenDepartment of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.ORCID 0000-0001-8042-7554
Kjeld HermansenDepartment of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.
Søren GregersenDepartment of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.

Funding

Aase og Ejnar Danielsens FondA.P. Møller og Hustru Chastine Mc-Kinney Møllers FondDanish Diabetes Academy NNF17SA0031406Ekhaga Foundation 2019-04Frode V. Nyegaard og Hustru's FondFuture Food innovationHelsefonden 19-B-0179Innovation Fund Denmark 9065-00126B
6 · The paper itself

Abstract

Aronia melanocarpa berries are rich in antioxidants and possess a high antioxidant capacity. Aronia berries have shown potential in type 2 diabetes mellitus (T2DM) treatment, and previous studies indicate improvements in glycemia after supplementation. Unfortunately, the effectiveness of aronia berries is limited by the low bioavailability of aronia, which fermentation could potentially overcome. The objective of this study was to compare the effects of fermented or non-fermented aronia pulp with placebo in subjects with T2DM. This study was a triple-blinded, triple-crossover study with eight-week intervention periods with fermented aronia extract (FAE), non-fermented aronia extract (AE), and placebo. Extracts were incorporated in snack bars with 37% aronia (FAE or AE) or wheat bran (placebo) and 63% raisins and coconut oil. Pre- and post-treatment period, we did fasting blood samples, including hemoglobin A1c, fructosamine, insulin, glucose, glucagon-like peptide-1, glucose-dependent insulinotropic peptide (GIP) and glucagon, oral glucose tolerance tests, and anthropometric measurements. Of 36 randomized participants, 23 completed the trial. Aside from a higher increase in GIP after FAE supplementation compared to after placebo supplementation, aronia extracts had no effect. The increase in GIP levels after FAE supplementation may hold potential benefits, but the overall clinical impact remains unclear.

Indexed as

Diabetes Mellitus, Type 2PhotiniaAntioxidantsCross-Over StudiesHumansInsulinPlant ExtractsAntioxidantsInsulinPlant ExtractsanthocyaninsantioxidantsAronia melanocarpadietary supplementpolyphenolsrandomized controlled trialtype 2 diabetes

Identifiers

PMID37836472
PMCPMC10574687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.