Evidence map›Paper›PMID 37835570›Full record

ReviewCancers2023

Fatty Pancreas Is a Risk Factor for Pancreatic Cancer: A Systematic Review and Meta-Analysis of 2956 Patients.

Mónika Lipp, Dorottya Tarján, Jimin Lee, Ádám Zolcsák, Eszter Szalai, Brigitta Teutsch, Nándor Faluhelyi, Bálint Erőss, Péter Hegyi, Alexandra Mikó

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mónika LippInstitute of Pancreatic Diseases, Semmelweis University, 1083 Budapest, Hungary.
Dorottya TarjánInstitute of Pancreatic Diseases, Semmelweis University, 1083 Budapest, Hungary.
Jimin LeeCentre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Ádám ZolcsákCentre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Eszter SzalaiCentre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0003-2276-7109
Brigitta TeutschCentre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Nándor FaluhelyiCentre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.
Bálint ErőssInstitute of Pancreatic Diseases, Semmelweis University, 1083 Budapest, Hungary.
Péter HegyiInstitute of Pancreatic Diseases, Semmelweis University, 1083 Budapest, Hungary.
Alexandra MikóCentre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-5322-4425
Semmelweis University · HU

Funding

Hungarian Ministry of Innovation and Technology, National Research, Development and Inno-vation Fund TKP2021-EGA-23National Research, Development and Innovation Fund ÚNKP-22-3National Research, Development and Innovation Fund ÚNKP-22-3-I-PTE-1693National Research, Development and Innovation Fund ÚNKP-22-5National Research, Development and Innovation Office Research Fund FK131864National Research, Development and Innovation Office Research Fund K131996Translational Neuroscience National Laboratory program RRF-2.3.1-21-2022-00011
6 · The paper itself

Abstract

Pancreatic cancer (PC) is one of the most lethal cancers worldwide. Recently, fatty pancreas (FP) has been studied thoroughly, and although its relationship to PC is not fully understood, FP is suspected to contribute to the development of PC. We aimed to assess the association between PC and FP by conducting a systematic review and meta-analysis. We systematically searched three databases, MEDLINE, Embase, and CENTRAL, on 21 October 2022. Case-control and cross-sectional studies reporting on patients where the intra-pancreatic fat deposition was determined by modern radiology or histology were included. As main outcome parameters, FP in patients with and without PC and PC in patients with and without FP were measured. Proportion and odds ratio (OR) with a 95% confidence interval (CI) were used for effect size measure. PC among patients with FP was 32% (OR 1.32; 95% CI 0.42-4.16). However, the probability of having FP among patients with PC was more than six times higher (OR 6.13; 95% CI 2.61-14.42) than in patients without PC, whereas the proportion of FP among patients with PC was 0.62 (95% CI 0.42-0.79). Patients identified with FP are at risk of developing PC. Proper screening and follow-up of patients with FP may be recommended.

Indexed as

metabolic syndromeobesitypancreatic adenocarcinomapancreatic steatosisrisk factors

Identifiers

PMID37835570
PMCPMC10571813
OpenAlexW4387435869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.