Evidence map›Paper›PMID 37835549›Full record

ArticleCancers2023

Immune Cell Deconvolution Reveals Possible Association of γδ T Cells with Poor Survival in Head and Neck Squamous Cell Carcinoma.

Anuraag S Parikh, Yize Li, Angela Mazul, Victoria X Yu, Wade Thorstad, Jason Rich, Randal C Paniello, Salvatore M Caruana, Scott H Troob, Ryan S Jackson and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anuraag S ParikhDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Yize LiDepartment of Medicine, Division of Oncology, Washington University in St. Louis, St. Louis, MO 63110, USA.ORCID 0000-0003-1074-281X
Angela MazulDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.
Victoria X YuDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wade ThorstadDepartment of Radiation Oncology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Jason RichDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.
Randal C PanielloDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.
Salvatore M CaruanaDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Scott H TroobDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Ryan S JacksonDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.
Patrik PipkornDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.
Paul ZolkindDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.
Zongtai QiDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.
Douglas AdkinsDepartment of Medicine, Division of Oncology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Li DingDepartment of Medicine, Division of Oncology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Sidharth V PuramDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0003-3543-889X

Funding

Deciphering epigenetically-regulated pathways to improve targeted therapy for invasion and metastasis in head and neck cancerR01DE032865 · NIDCR · WASHINGTON UNIVERSITY · PI Robi D Mitra, Sidharth Venkata Puram · 2023 to 2026
$2.4M
Dissecting hybrid epithelial-mesenchymal states in head and neck cancerR01DE032371 · NIDCR · WASHINGTON UNIVERSITY · PI Sidharth Venkata Puram · 2023 to 2026
$1.6M
Understanding programs of invasion and metastasis in head and neck cancerK08CA237732 · NCI · WASHINGTON UNIVERSITY · PI PURAM, SIDHARTH VENKATA · 2019 to 2023
$984k
3D Culture Models of Partial-EMT and Its Regulation in Oral Cavity Squamous Cell CarcinomaK08DE033093 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PARIKH, ANURAAG SUHRID · 2023 to 2025
$827k
RNA modification and the regulation of partial EMT in head and neck cancerR21DE031072 · NIDCR · WASHINGTON UNIVERSITY · PI PURAM, SIDHARTH VENKATA · 2021 to 2022
$433k
An inducible molecular memory system to unravel the mechanisms of drug resistance in head and neck cancerR21DE031366 · NIDCR · WASHINGTON UNIVERSITY · PI MITRA, ROBI D, PURAM, SIDHARTH VENKATA · 2022 to 2023
$433k
NCI NIH HHS 1K08CA237732NCI NIH HHS K08 CA237732NIDCR NIH HHS K08 DE033093NIDCR NIH HHS R01 DE032371NIDCR NIH HHS R01 DE032865NIDCR NIH HHS R21 DE031072NIDCR NIH HHS R21 DE031366
6 · The paper itself

Abstract

(1) Background: The role of rare immune cell subtypes in many solid tumors, chief among them head and neck squamous cell carcinoma (HNSCC), has not been well defined. The objective of this study was to assess the association between proportions of common and rare immune cell subtypes and survival outcomes in HNSCC. (2) Methods: In this cohort study, we utilized a deconvolution approach based on the CIBERSORT algorithm and the LM22 signature matrix to infer proportions of immune cell subtypes from 517 patients with untreated HPV-negative HNSCC from The Cancer Genome Atlas. We performed univariate and multivariable survival analysis, integrating immune cell proportions with clinical, pathologic, and genomic data. (3) Results: We reliably deconvolved 22 immune cell subtypes in most patients and found that the most common immune cell types were M0 macrophages, M2 macrophages, and memory resting CD4 T cells. In the multivariable analysis, we identified advanced N stage and the presence of γδ T cells as independently predictive of poorer survival. (4) Conclusions: We uncovered that γδ T cells in the tumor microenvironment were a negative predictor of survival among patients with untreated HNSCC. Our findings underscore the need to better understand the role of γδ T cells in HNSCC, including potential pro-tumorigenic mechanisms, and whether their presence may predict the need for alternative therapy approaches.

Indexed as

deconvolutiongamma−delta T cellshead and neck squamous cell carcinomaimmune microenvironmentsurvival

Identifiers

PMID37835549
PMCPMC10571517

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.