Evidence map›Paper›PMID 37835542›Full record

ArticleCancers2023

The Association between Mediated Deprivation and Ovarian Cancer Survival among African American Women.

Andrew B Lawson, Joanne Kim, Courtney Johnson, Kendra L Ratnapradipa, Anthony J Alberg, Maxwell Akonde, Theresa Hastert, Elisa V Bandera, Paul Terry, Hannah Mandle and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrew B LawsonDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Joanne KimDepartment of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH 43210, USA.
Courtney JohnsonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Kendra L RatnapradipaDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-0265-2400
Anthony J AlbergDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Maxwell AkondeDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0002-0869-1219
Theresa HastertDepartment of Oncology, Wayne State University School of Medicine, Population Studies and Disparities Research Program, Karmanos Cancer Institute, Detroit, MI 48201, USA.ORCID 0000-0001-6251-6422
Elisa V BanderaCancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08625, USA.
Paul TerryDepartment of Medicine, University of Tennessee Medical Center-Knoxville, Knoxville, TN 37920, USA.
Hannah MandleDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Michele L CoteBren Simon Comprehensive Cancer Center, Indiana University Melvin, Inidianapolis, IN 46202, USA.
Melissa BondyDepartment of Epidemiology and Population Health, College of Medicine, Stanford University, Stanford, CA 94305, USA.
Jeffrey MarksDepartment of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Lauren C PeresDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.ORCID 0000-0002-6620-8600
Joellen SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-0990-9339
Edward S PetersDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-4928-6532

Funding

Epidemiology of Ovarian Cancer in African-American WomenR01CA142081 · NCI · UNIVERSITY OF VIRGINIA · PI SCHILDKRAUT, JOELLEN M. · 2010 to 2015
$10.6M
Ovarian Cancer Survival in African-American WomenR01CA237318 · NCI · EMORY UNIVERSITY · PI LAWSON, ANDREW B., SCHILDKRAUT, JOELLEN M. · 2020 to 2024
$5.9M
NCI NIH HHS R01 CA142081NCI NIH HHS R01 CA237318NCI NIH HHS R01CA237318
6 · The paper itself

Abstract

backgroundDeprivation indices are often used to adjust for socio-economic disparities in health studies. Their role has been partially evaluated for certain population-level cancer outcomes, but examination of their role in ovarian cancer is limited. In this study, we evaluated a range of well-recognized deprivation indices in relation to cancer survival in a cohort of self-identified Black women diagnosed with ovarian cancer. This study aimed to determine if clinical or diagnostic characteristics lie on a mediating pathway between socioeconomic status (SES) and deprivation and ovarian cancer survival in a minority population that experiences worse survival from ovarian cancer.

methodsWe used mediation analysis to look at the direct and indirect causal effects of deprivation indices with main mediators of the SEER stage at diagnosis and residual disease. The analysis employed Bayesian structural equation models with variable selection. We applied a joint Bayesian structural model for the mediator, including a Weibull mixed model for the vital outcome with deprivation as exposure. We selected modifiers via a Monte Carlo model selection procedure.

resultsThe results suggest that high SES-related indices, such as Yost, Kolak urbanicity (URB), mobility (MOB) and SES dimensions, and concentrated disadvantage index (CDI), all have a significant impact on improved survival. In contrast, area deprivation index (ADI)/Singh, and area level poverty (POV) did not have a major impact. In some cases, the indirect effects have very wide credible intervals, so the total effect is not well estimated despite the estimation of the direct effect.

conclusionsFirst, it is clear that commonly used indices such as Yost, or CDI both significantly impact the survival experience of Black women diagnosed with epithelial ovarian cancer. In addition, the Kolak dimension indices (URB, MOB, mixed immigrant: MICA and SES) also demonstrate a significant association, depending on the mediator. Mediation effects differ according to the mediator chosen.

Indexed as

Bayesiancausal mediationCDIdeprivation indicesKolakmixed effect modelsovarian cancerSinghstructural equationsurvivalYost

Identifiers

PMID37835542
PMCPMC10571563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.