Evidence map›Paper›PMID 37835471›Full record

ArticleCancers2023

COVID-19 Infection despite Previous Vaccination in Cancer Patients and Healthcare Workers: Results from a French Prospective Multicenter Cohort (PAPESCO-19).

Valérie Seegers, Guillaume Rousseau, Ke Zhou, Audrey Blanc-Lapierre, Frédéric Bigot, Hakim Mahammedi, Aurélien Lambert, Camille Moreau-Bachelard, Mario Campone, Thierry Conroy and 3 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valérie SeegersDepartment of Biostatistics, Institut de Cancérologie de l'Ouest, 44805 Saint-Herblain, France.ORCID 0000-0003-1404-0292
Guillaume RousseauDepartment of Biopathology, Institut de Cancérologie de l'Ouest, 49055 Angers, France.ORCID 0000-0002-0621-1621
Ke ZhouDepartment of Human and Social Sciences, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.ORCID 0000-0003-1221-0008
Audrey Blanc-LapierreDepartment of Biostatistics, Institut de Cancérologie de l'Ouest, 44805 Saint-Herblain, France.
Frédéric BigotDepartment of Medical Oncology, Institut de Cancérologie de l'Ouest, 49055 Angers, France.
Hakim MahammediDepartment of Medical Oncology, Centre Jean Perrin, 63011 Clermont-Ferrand, France.
Aurélien LambertDepartment of Medical Oncology, Institut de Cancérologie de Lorraine, 54511 Vandoeuvre-lès-Nancy, France.ORCID 0000-0001-9990-1201
Camille Moreau-BachelardDepartment of Medical Oncology, Institut de Cancérologie de l'Ouest, 44805 Saint-Herblain, France.ORCID 0000-0002-4289-8483
Mario CamponeDepartment of Medical Oncology, Institut de Cancérologie de l'Ouest, 44805 Saint-Herblain, France.
Thierry ConroyDepartment of Medical Oncology, Institut de Cancérologie de Lorraine, 54511 Vandoeuvre-lès-Nancy, France.ORCID 0000-0001-7548-284X
Frédérique Penault-LlorcaDepartment of Biopathology, Centre Jean Perrin, 63011 Clermont-Ferrand, France.
Martine M BellangerDepartment of Human and Social Sciences, Institut de Cancérologie de l'Ouest (ICO), 44805 Saint-Herblain, France.ORCID 0000-0002-1892-8961
Jean-Luc RaoulDepartment of Clinical Research, Institut de Cancérologie de l'Ouest, 44805 Saint-Herblain, France.ORCID 0000-0001-6305-8953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a multicenter prospective cohort of cancer patients (CP; n = 840) and healthcare workers (HCWs; n = 935) vaccinated against COVID-19, we noticed the following: i/after vaccination, 4.4% of HCWs and 5.8% of CP were infected; ii/no characteristic was associated with post-vaccine COVID-19 infections among HCWs; iii/CP who developed infections were younger, more frequently women (NS), more frequently had gastrointestinal, gynecological, or breast cancer and a localized cancer stage; iv/CP vaccinated while receiving chemotherapy or targeted therapy had (NS) more breakthrough infections after vaccination than those vaccinated after these treatments; the opposite was noted with radiotherapy, immunotherapy, or hormonotherapy; v/most COVID-19 infections occurred either during the Alpha wave (11/41 HCW, 20/49 CP), early after the first vaccination campaign started, or during the Omicron wave (21/41 HCW, 20/49 CP), more than 3 months after the second dose; vi/risk of infection was not associated with values of antibody titers; vii/the outcome of these COVID-19 infections after vaccination was not severe in all cases. To conclude, around 5% of our CPs or HCWs developed a COVID-19 infection despite previous vaccination. The outcome of these infections was not severe.

Indexed as

breakthrough infectionscancer patientsCOVID-19 vaccineFrancehealthcare workers

Identifiers

PMID37835471
PMCPMC10571737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.