Evidence map›Paper›PMID 37835468›Full record

ReviewCancers2023

Exploring the Potential of Non-Coding RNAs as Liquid Biopsy Biomarkers for Lung Cancer Screening: A Literature Review.

Edoardo Garbo, Benedetta Del Rio, Giorgia Ferrari, Massimiliano Cani, Valerio Maria Napoli, Valentina Bertaglia, Enrica Capelletto, Christian Rolfo, Silvia Novello, Francesco Passiglia

Abstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Circulating long noncoding RNA: New frontiers in biomarker research for mood disorders.Genomic psychiatry : advancing science from genes to society · 2025
    Article
  11. Review
  12. Involvement of lncRNA in cancer diagnosis and prognosis and clinical implications.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  13. Lung cancer screening: where do we stand?Breathe (Sheffield, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Edoardo GarboDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.ORCID 0000-0003-2394-9895
Benedetta Del RioDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.ORCID 0000-0003-3053-6597
Giorgia FerrariDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.ORCID 0000-0001-6424-7211
Massimiliano CaniDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.
Valerio Maria NapoliDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.
Valentina BertagliaDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.
Enrica CapellettoDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.
Christian RolfoCenter for Thoracic Oncology, Tisch Cancer Institute, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Silvia NovelloDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.
Francesco PassigliaDepartment of Oncology, University of Turin, San Luigi Hospital, 10124 Orbassano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer represent the leading cause of cancer mortality, so several efforts have been focused on the development of a screening program. To address the issue of high overdiagnosis and false positive rates associated to LDCT-based screening, there is a need for new diagnostic biomarkers, with liquid biopsy ncRNAs detection emerging as a promising approach. In this scenario, this work provides an updated summary of the literature evidence about the role of non-coding RNAs in lung cancer screening. A literature search on PubMed was performed including studies which investigated liquid biopsy non-coding RNAs biomarker lung cancer patients and a control cohort. Micro RNAs were the most widely studied biomarkers in this setting but some preliminary evidence was found also for other non-coding RNAs, suggesting that a multi-biomarker based liquid biopsy approach could enhance their efficacy in the screening context. However, further studies are needed in order to optimize detection techniques as well as diagnostic accuracy before introducing novel biomarkers in the early diagnosis setting.

Indexed as

liquid biopsylung cancernon-coding RNAscreening

Identifiers

PMID37835468
PMCPMC10571819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.