Evidence map›Paper›PMID 37835450›Full record

ArticleCancers2023

DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.

Jian Li, Yaqiong Zhang, Fangzhou Ye, Peiyu Qian, Zhe Qin, Deming Li, Li Ye, Li Feng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jian LiEndoscopy Center, Minhang Hospital, Fudan University, Shanghai 201199, China.
Yaqiong ZhangEndoscopy Center, Minhang Hospital, Fudan University, Shanghai 201199, China.
Fangzhou YeEndoscopy Center, Minhang Hospital, Fudan University, Shanghai 201199, China.
Peiyu QianInstitutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Zhe QinEndoscopy Center, Minhang Hospital, Fudan University, Shanghai 201199, China.
Deming LiEndoscopy Center, Minhang Hospital, Fudan University, Shanghai 201199, China.
Li YeSchool of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China.
Li FengEndoscopy Center, Minhang Hospital, Fudan University, Shanghai 201199, China.ORCID 0009-0009-7755-0805
Fudan University · CNMacau University of Science and Technology · MO

Funding

Major Discipline Construction of Minhang District, Shanghai 2020MWDXK03National Nature Science Foundation of China 8217100675
6 · The paper itself

Abstract

Chemotherapy is a classical method of cancer treatment. Cisplatin-based chemotherapy is a traditional and essential therapeutic approach in gastric cancer treatment. However, the development of drug resistance during treatment is a major obstacle that limits their further application, and molecular changes have occurred in the development of drug resistance. Here, we found that Dickkopf-related protein 1 (DKK1) is highly expressed in gastric cancer and related to poor prognosis in gastric cancer patients through public database mining. Next, we also identified that DKK1 is highly expressed in CDDP-resistant gastric cancer cell lines, supporting the notion that DKK1 is a necessary regulator of CDDP resistance. In terms of mechanistic research, our data reveal that DKK1 was able to activate the PI3K/AKT pathway and affect epithelial-to-mesenchymal transition, further contributing to CDDP resistance. Genetic knockdown and pharmacological inhibition of DKK1 recovered CDDP sensitivity both in vitro and in vivo. Therefore, our study highlights the potential of targeted inhibition of DKK1 to reverse CDDP resistance and alleviate metastatic properties in gastric cancer.

Indexed as

cancer therapeutic resistanceDickkopf-related protein 1epithelial-to-mesenchymal transitiongastric cancer

Identifiers

PMID37835450
PMCPMC10571993
OpenAlexW4387121128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.