Evidence map›Paper›PMID 37835444›Full record

ArticleCancers2023

Local Recurrence and Development of Spinal Cord Syndrome during Follow-Up after Surgical Treatment of Metastatic Spine Disease.

Peter Knöll, Moritz Lenschow, Maximilian Lenz, Volker Neuschmelting, Niklas von Spreckelsen, Sergej Telentschak, Sebastian Olbrück, Maximilian Weber, Johannes Rosenbrock, Peer Eysel and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Peter KnöllDepartment of Orthopedics, Trauma Surgery and Plastic Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Moritz LenschowDepartment of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.ORCID 0000-0003-0788-4681
Maximilian LenzDepartment of Orthopedics, Trauma Surgery and Plastic Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Volker NeuschmeltingDepartment of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Niklas von SpreckelsenDepartment of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.ORCID 0000-0002-9873-1711
Sergej TelentschakDepartment of General Neurosurgery, Center for Neurosurgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Sebastian OlbrückDepartment of Orthopedics, Trauma Surgery and Plastic Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.ORCID 0009-0000-9733-3589
Maximilian WeberDepartment of Orthopedics, Trauma Surgery and Plastic Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Johannes RosenbrockDepartment of Radiation Oncology, CyberKnife and Radiation Therapy, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Peer EyselDepartment of Orthopedics, Trauma Surgery and Plastic Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Sebastian G WalterDepartment of Orthopedics, Trauma Surgery and Plastic Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.ORCID 0000-0002-6203-8616
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical decompression (SD), with or without posterior stabilization followed by radiotherapy, is an established treatment for patients with metastatic spinal disease with epidural spinal cord compression (ESCC). This study aims to identify risk factors for occurrence of neurological compromise resulting from local recurrence.

methodsAll patients who received surgical treatment for metastatic spinal disease at our center between 2011 and 2022 were included in this study. Cases were evaluated for tumor entity, surgical technique for decompression (decompression, hemilaminectomy, laminectomy, corpectomy) neurological deficits, grade of ESCC, time interval to radiotherapy, and perioperative complications.

resultsA total of 747 patients were included in the final analysis, with a follow-up of 296.8 days (95% CI (263.5, 330.1)). During the follow-up period, 7.5% of the patients developed spinal cord/cauda syndrome (SCS). Multivariate analysis revealed prolonged time (>35 d) to radiation therapy as a solitary risk factor (

conclusionSurgical treatment of spinal metastatic disease improves patients' quality of life and Frankel grade, but radiation therapy needs to be scheduled within a time frame of a few weeks in order to reduce the risk of tumor-induced neurological compromise.

Indexed as

decompression surgeryESCCMSCCradiotherapyspinal cord syndromespinal metastasis

Identifiers

PMID37835444
PMCPMC10571549
OpenAlexW4387106491

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.