Evidence map›Paper›PMID 37835423›Full record

ArticleCancers2023

Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting.

Daisuke Nishizawa, Ryozo Morino, Rie Inoue, Seii Ohka, Shinya Kasai, Junko Hasegawa, Yuko Ebata, Kyoko Nakayama, Hiroyuki Sumikura, Masakazu Hayashida and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  6. International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Daisuke NishizawaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.ORCID 0000-0001-8286-4651
Ryozo MorinoDivision of Anesthesiology, Koujinkai Daiichi Hospital, Tokyo 125-0041, Japan.
Rie InoueAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Seii OhkaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Shinya KasaiAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Junko HasegawaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Yuko EbataAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Kyoko NakayamaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Hiroyuki SumikuraDepartment of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
Masakazu HayashidaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Miyuki YokotaDepartment of Anesthesiology, Cancer Institute Hospital, Tokyo 135-8550, Japan.
Kazutaka IkedaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.ORCID 0000-0001-8342-0278
Tokyo Metropolitan Institute of Medical Science · JPJuntendo University · JPThe Cancer Institute Hospital · JPToujinkai Hospital · JP

Funding

Asahi Kasei Pharma Open Innovation noneJapan Agency for Medical Research and Development JP19dk0307071Japan Agency for Medical Research and Development JP19ek0610011Japan Research Foundation for Clinical Pharmacology noneJapan Society for the Promotion of Science 17H04324Japan Society for the Promotion of Science 17K08970Japan Society for the Promotion of Science 18K08829Japan Society for the Promotion of Science 20K09259Japan Society for the Promotion of Science 21H03028Japan Society for the Promotion of Science 22790518Japan Society for the Promotion of Science 23390377Japan Society for the Promotion of Science 24790544Japan Society for the Promotion of Science 26293347Japan Society for the Promotion of Science JP22H04922 [AdAMS]Ministry of Health, Labour, and Welfare H26-Kakushintekigan-ippan-060Smoking Research Foundation none
6 · The paper itself

Abstract

Considerable individual differences are widely observed in the incidence of postoperative nausea and vomiting (PONV). We conducted a genome-wide association study (GWAS) to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to PONV by utilizing whole-genome genotyping arrays with more than 950,000 markers. The subjects were 806 patients who provided written informed consent and underwent elective surgery under general anesthesia with propofol or desflurane. The GWAS showed that two SNPs, rs2776262 and rs140703637, in the

Indexed as

anesthesiagenome-wide association studypostoperative nausea and vomitingpropofolsingle-nucleotide polymorphisms

Identifiers

PMID37835423
PMCPMC10571790
OpenAlexW4387048649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.