Evidence map›Paper›PMID 37835009›Full record

ReviewJournal of clinical medicine2023

Thyroid Autoimmunity and SARS-CoV-2 Infection.

Poupak Fallahi, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Armando Patrizio, Eugenia Balestri, Valeria Mazzi, Salvatore Benvenga, Gilda Varricchi, Laura Gragnani and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Proteomic Applications in Vaccine Development.Advances in experimental medicine and biology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
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  16. Review
  17. Article
  18. Article
  19. Detection of autoantibodies in severe COVID-19 patients two years after hospital discharge.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Poupak FallahiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Giusy EliaDepartment of Surgery, Medical and Molecular Pathology and of Critical Area, University of Pisa, 56126 Pisa, Italy.
Francesca RagusaDepartment of Surgery, Medical and Molecular Pathology and of Critical Area, University of Pisa, 56126 Pisa, Italy.
Sabrina Rosaria PaparoDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Armando PatrizioDepartment of Emergency Medicine, Azienda Ospedaliero-Universitaria Pisana, 56126 Pisa, Italy.ORCID 0000-0003-1090-4794
Eugenia BalestriDepartment of Surgery, Medical and Molecular Pathology and of Critical Area, University of Pisa, 56126 Pisa, Italy.
Valeria MazziDepartment of Surgery, Medical and Molecular Pathology and of Critical Area, University of Pisa, 56126 Pisa, Italy.
Salvatore BenvengaDepartment of Clinical and Experimental Medicine-Endocrinology, University of Messina, 98122 Messina, Italy.
Gilda VarricchiDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-9285-4657
Laura GragnaniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy.
Chiara BotriniDepartment of Surgery, Medical and Molecular Pathology and of Critical Area, University of Pisa, 56126 Pisa, Italy.
Enke BaldiniDepartment of Experimental Medicine, "Sapienza" University of Rome, 00185 Rome, Italy.ORCID 0000-0002-8999-1386
Marco CentanniDepartment of Medico-Surgical Sciences and Biotechnologies, Endocrinology Section, ''Sapienza'' University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0661-1649
Clodoveo FerriRheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Alessandro AntonelliDepartment of Surgery, Medical and Molecular Pathology and of Critical Area, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-5211-6342
Silvia Martina FerrariDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
University of Pisa · ITASL Roma · ITAzienda Ospedaliera Universitaria Pisana · ITInstitute for Experimental Endocrinology and Oncology · ITSapienza University of Rome · ITUniversity of Messina · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological culprit of COronaVIrus Disease 19 (COVID-19), can enter the cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which has been found in several tissues including in endocrine organs, such as the ovaries, testes, pancreas, and thyroid. Several thyroid disorders have been associated with SARS-CoV-2 infection [subacute thyroiditis (SAT), thyrotoxicosis, and non-thyroidal illness syndrome (NTIS)] and, in part, they are believed to be secondary to the local virus replication within the gland cells. However, as documented for other viruses, SARS-CoV-2 seems to interfere with several aspects of the immune system, inducing the synthesis of autoantibodies and triggering latent or new onset autoimmune disease (AID), including autoimmune thyroid disease (AITD), such as Hashimoto Thyroiditis (HT) and Graves' disease (GD). Several mechanisms have been hypothesized to explain this induction of autoimmunity by SARS-CoV-2 infection: the immune system hyper-stimulation, the molecular mimicry between the self-antigens of the host and the virus, neutrophils extracellular traps, and finally, the virus induced transcriptional changes in the immune genes; nonetheless, more evidence is needed especially from large, long-term cohort studies involving COVID-19 patients, to establish or reject this pathogenetic relationship.

Indexed as

autoimmune thyroid diseasesCOVID-19SARS-CoV-2 infectionsubacute thyroiditisthyrotoxicosis

Identifiers

PMID37835009
PMCPMC10573843
OpenAlexW4387369810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.