Evidence map›Paper›PMID 37834994›Full record

ArticleJournal of clinical medicine2023

Practical Management of Biosimilar Use in Inflammatory Bowel Disease (IBD): A Global Survey and an International Delphi Consensus.

Ferdinando D'Amico, Virginia Solitano, Fernando Magro, Pablo A Olivera, Jonas Halfvarson, David Rubin, Axel Dignass, Sameer Al Awadhi, Taku Kobayashi, Natália Sousa Freitas Queiroz and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Update on Pregnancy in Inflammatory Bowel Disease.Gastroenterology & hepatology · 2026
    Article
  2. Review
  3. TL1A Inhibition in Inflammatory Bowel Disease: A Pipeline Review.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Biosimilars in IBD: What Every Clinician Needs to Know.Current gastroenterology reports · 2024
    Review
  9. Review
  10. Raising the bar in ulcerative colitis management.Therapeutic advances in gastroenterology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 14 institutions in 13 countries.

Ferdinando D'AmicoGastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, 20132 Milan, Italy.
Virginia SolitanoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.ORCID 0000-0002-2935-6778
Fernando MagroCINTESIS@RISE, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal.
Pablo A OliveraGastroenterology Department, CEMIC, Buenos Aires C1425ASS, Argentina.ORCID 0000-0002-2740-6102
Jonas HalfvarsonDepartment of Gastroenterology, Faculty of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.ORCID 0000-0003-0122-7234
David RubinThe University of Chicago Medicine Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL 60637, USA.ORCID 0000-0001-5647-1723
Axel DignassDepartment of Medicine I, Agaplesion Markus Hospital, Goethe University, 60323 Frankfurt am Main, Germany.
Sameer Al AwadhiDigestive Diseases Unit, Rashid Hospital, Dubai P.O. Box 4545, United Arab Emirates.ORCID 0000-0002-1611-3451
Taku KobayashiCenter for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo 108-8642, Japan.
Natália Sousa Freitas QueirozHealth Sciences Graduate Program, School of Medicine, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0003-2857-0825
Marta CalvoIBD Unit, Gastroenterology, Hospital Universitario Puerta de Hierro Majalahonda, 28222 Madrid, Spain.
Paulo Gustavo KotzeColorectal Surgery Unit, Hospital Universitário Cajuru, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, Brazil.ORCID 0000-0002-9632-6691
Subrata GhoshAPC Microbiome Ireland, College of Medicine and Health, University College Cork, T12 E138 Cork, Ireland.ORCID 0000-0002-1713-7797
Laurent Peyrin-BirouletDepartment of Gastroenterology, Nancy University Hospital, F-54500 Vandœuvre-lès-Nancy, France.
Silvio DaneseGastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0001-7341-1351
Pontifícia Universidade Católica do Paraná · BRGoethe University Frankfurt · DEHospital Universitario Puerta de Hierro Majadahonda · ESHumanitas University · ITInserm · FRKitasato Institute Hospital · JPLunenfeld-Tanenbaum Research Institute · CAÖrebro University · SERashid Hospital · AEUniversidade do Porto · PTUniversity College Cork · IEUniversity of Chicago · USVita-Salute San Raffaele University · ITWestern University · CA

Funding

Sandoz na
6 · The paper itself

Abstract

As the patents for biologic originator drugs expire, biosimilars are emerging as cost-effective alternatives within healthcare systems. Addressing various challenges in the clinical management of inflammatory bowel disease (IBD) remains crucial. To shed light on physicians' current knowledge, beliefs, practical approaches, and concerns related to biosimilar adoption-whether initiating a biosimilar, transitioning from an originator to a biosimilar, or switching between biosimilars (including multiple switches and reverse switching)-a global survey was conducted. Fifteen physicians with expertise in the field of IBD from 13 countries attended a virtual international consensus meeting to develop practical guidance regarding biosimilar adoption worldwide, considering the survey results. This consensus centered on 10 key statements covering biosimilar effectiveness, safety, indications, rationale, multiple switches, therapeutic drug monitoring of biosimilars, non-medical switching, and future perspectives. Ultimately, the consensus affirmed that biosimilars are equally effective and safe when compared to originator drugs. They are considered suitable for both biologic-naïve patients and those who have previously been treated with originator drugs, with cost reduction being the primary motivation for transitioning from an originator drug to a biosimilar.

Indexed as

biologic drugbio-originatorsbiosimilarsCrohn’s diseaseeconomicsIBDinterchangeabilityulcerative colitis

Identifiers

PMID37834994
PMCPMC10574001
OpenAlexW4387311003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.