ArticleJournal of clinical medicine2023
Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour.
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Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 18 citations in OpenAlex.
- Critical Insights into Parathyroid Cancer.Journal of cancer science and clinical therapeutics · 2026Article
- Is atypical parathyroid tumor a different clinical entity than parathyroid adenoma and carcinoma? A retrospective review of a large single-center case series.Updates in surgery · 2026Article
- Parathyroidectomy and the use of ioPTH. A survey of the United Italian Society of Endocrine Surgery (SIUEC).Updates in surgery · 2026Article
- Parathyroid carcinoma: epidemiology and genetics.Endocrine oncology (Bristol, England) · 2026Review
- Primary Hyperparathyroidism: 18F-Fluorocholine PET/CT vs. 4D-CT for Parathyroid Identification: Toward a Comprehensive Diagnostic Framework-An Updated Review and Recommendations.Journal of clinical medicine · 2025Review
- Synchronous Multiple Parathyroid Carcinoma: A Challenging Diagnosis Influencing Optimal Primary Treatment-A Literature Review to Guide Clinical Decision-Making.Journal of clinical medicine · 2025Review
- Potential higher malignancy of nonfunctional parathyroid carcinoma: a case series study.Gland surgery · 2025Article
- Article
- The impact of management traps on surgical strategies in parathyroid benign and malignant tumors-related PHPT: a retrospective cohort study.Frontiers in oncology · 2025Article
- Thyroid nodule with cytological outcome of indeterminate lesion with low risk of malignancy found to be parathyroid adenoma. A case report and minireview of literature.Frontiers in endocrinology · 2025Review
- A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors.Frontiers in endocrinology · 2025Article
- Metastatic parathyroid carcinoma diagnosed after five surgical attempts: a case report and review of the literature.Journal of cardiothoracic surgery · 2024Review
- Article
- Management of surgical diseases of Primary Hyperparathyroidism: indications of the United Italian Society of Endocrine Surgery (SIUEC).Updates in surgery · 2024Review
- Management and surgical treatment of parathyroid carcinoma: a 6-year experience of a single centre of endocrine surgery unit.Frontiers in endocrinology · 2023Observational
- Intraoperative parathyroid hormone monitoring in parathyroidectomy for hyperparathyroidism: a protocol for a network meta-analysis of diagnostic test accuracy.Frontiers in surgery · 2023Article
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Authors and funding
45 authors at 20 institutions in 1 country.
Angela GurradoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.ORCID 0000-0002-2009-5831
Alessandro PasculliDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.ORCID 0000-0003-2276-2383
Nicola AveniaGeneral and Endocrine Surgery Unit, S. Maria University Hospital, University of Perugia, 05100 Terni, Italy.
Rocco BellantoneDivision of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Marco BoniardiGeneral Oncology and Mini-Invasive Surgery Department, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.
Isabella Merante BoschinEndocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, 35143 Padua, Italy.
Pietro Giorgio CalòDepartment of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.ORCID 0000-0001-9637-1145
Michele CamandonaDepartment of Surgical Sciences, Molinette Hospital, University of Turin, 10126 Turin, Italy.
Giuseppe CavallaroDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University, 00185 Rome, Italy.ORCID 0000-0001-7121-2295
Fabio CianchiDigestive Surgery Unit, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-6936-8693
Giovanni ConzoDivision of General, Oncological, Mini-Invasive and Obesity Surgery, Department of Medical and Traslational Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Vito D'AndreaDepartment of Surgical Sciences, Sapienza University, 00185 Rome, Italy.
Carmela De CreaUOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Loredana De PasqualeHead and Neck Surgery Department, San Paolo Hospital, 20142 Milan, Italy.
Paolo Del RioDepartment of General and Specialist Surgery, Parma University Hospital, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-6776-5441
Giovanna Di MeoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.ORCID 0000-0002-7012-8654
Gianlorenzo DionigiDivision of Surgery, Istituto Auxologico Italiano IRCCS, 20122 Milan, Italy.
Chiara DobrinjaDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy.
Giovanni DocimoDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, 80138 Naples, Italy.
Fausto FamàDepartment of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital "G. Martino", 98125 Messina, Italy.ORCID 0000-0002-9017-1991
Attilio GalimbertiDepartment of Surgery, Legnano Hospital, 20025 Legnano, Italy.
Laura GiacomelliDepartment of General and Speciality Surgery, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-3598-7522
Giuseppa GraceffaDepartment of Surgical Oncological and Oral Sciences, University of Palermo, 90127 Palermo, Italy.
Maurizio IacoboneEndocrine Surgery Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, 35143 Padua, Italy.ORCID 0000-0002-6057-4642
Nadia InnaroUnit of Endocrine Surgery, AOU "Dulbecco", University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Celestino Pio LombardiDivision of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.
Gabriele MaterazziEndocrine Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Area, University Hospital of Pisa, 56121 Pisa, Italy.
Fabio MedasDepartment of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.ORCID 0000-0002-9546-0178
Barbara MullinerisUnit of General Surgery, Emergency and New Technologies, Modena Hospital, 41126 Modena, Italy.
Luigi OraganoSurgical Unit of General Surgery, "San Biagio" Hospital, 28845 Domodossola, Italy.ORCID 0000-0002-2528-2708
Nicola PalestiniCandiolo Cancer Institute, Fondazione Piemontese per l'Oncologia, 10060 Candiolo, Italy.
Giuliano PerigliDigestive Surgery Unit, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-2271-5766
Angela PezzollaDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.
Francesco Paolo PreteDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.ORCID 0000-0003-0426-8752
Marco RaffaelliUOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, 00168 Rome, Italy.ORCID 0000-0002-1259-2491
Giuseppina RenzulliUnit of Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.
Lodovico RosatoDepartment of Surgery-ASL TO4, Ivrea Hospital, 10015 Ivrea, Italy.
Gregorio ScerrinoDepartment of Surgical Oncological and Oral Sciences, University of Palermo, 90127 Palermo, Italy.
Lucia Ilaria SgaramellaDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.ORCID 0000-0002-6087-4119
Salvatore SorrentiDepartment of Surgery, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-0427-6648
Carlotta TestiniDigestive Surgery Unit, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Massimiliano VerouxDepartment of Medical and Surgical Sciences and Advanced Technologies, University of Catania, 95100 Catania, Italy.ORCID 0000-0002-2780-6421
Guido GasparriDepartment of Surgical Sciences, Molinette Hospital, University of Turin, 10126 Turin, Italy.
Mario TestiniDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University Medical School of Bari, 70124 Bari, Italy.ORCID 0000-0002-9297-4894
pTRANI Study Group
University of Bari Aldo Moro · ITSapienza University of Rome · ITUniversity of Florence · ITAgostino Gemelli University Polyclinic · ITFondazione Ricerca Molinette · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Cagliari · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Padua · ITUniversity of Palermo · ITAzienda Ospedaliera Ospedale Civile di Legnano · ITAzienda Ospedaliera Universitaria Pisana · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITCandiolo Cancer Institute · ITMagna Graecia University · ITOspedale Civile Di Ivrea · ITOspedale San Paolo · ITUniversity of Catania · ITUniversity of Milan · ITUniversity of Parma · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics and improve its differentiation from the atypical parathyroid tumour (APT).
methodsAll relevant information was collected about PC and APT patients treated between 2009 and 2021.
resultsAmong 8361 parathyroidectomies, 351 patients (mean age 59.0 ± 14.5; F = 210, 59.8%) were divided into the APT (n = 226, 2.8%) and PC group (n = 125, 1.5%). PC showed significantly higher rates (
conclusionsSymptomatic hyperparathyroidism, high PTH and albumin-corrected serum calcium values, and a US diameter >3 cm may be considered features differentiating PC from APT. 2022 WHO criteria did not impact the diagnosis.
Indexed as
2022 WHO criteriaatypical thyroid tumourhyperparathyroidismparathyroid carcinomaparathyroidectomy
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