Evidence map›Paper›PMID 37834863›Full record

ArticleJournal of clinical medicine2023

The Association of

Samran Sheriff, Ting Shen, Danit Saks, Angela Schultz, Heather Francis, Wei Wen, Jiyang Jiang, Mehdi Mirzaei, Veer Gupta, Maria Fiatarone Singh and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Alzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Samran SheriffMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Ting ShenDepartment of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-0057-232X
Danit SaksMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Angela SchultzMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Heather FrancisSchool of Psychological Sciences, Macquarie University, Sydney, NSW 2019, Australia.ORCID 0000-0002-7223-7782
Wei WenCentre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW 2052, Australia.
Jiyang JiangCentre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-2147-6302
Mehdi MirzaeiMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Veer GuptaSchool of Medicine, Deakin University, Melbourne, VIC 3125, Australia.
Maria Fiatarone SinghSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.ORCID 0000-0002-1897-8707
Perminder S SachdevCentre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-9595-3220
Stuart L GrahamMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Vivek GuptaMacquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0002-0202-7843
Macquarie University · AUDeakin University · AUUNSW Sydney · AURoyal North Shore Hospital · AUShanghai Jiao Tong University · CNThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the relationship between the apolipoprotein E (APOE) ε4 allele and retinal structural and vascular characteristics in older adult participants from several research studies. We also studied the relationship between these structural and vascular characteristics with multifocal visual evoked potential (mfVEP) indices, neuropsychological parameters and MRI brain volumes in these participants.

methodsIn this study, 109 participants with a mean (SD) age of 67.1 (9.0) years were recruited. Participants were classified as APOE ε4 carriers or non-carriers based on the presence or absence of the ε4 allele. Baseline measurements included peripapillary retinal nerve fibre layer optical coherence tomography (RNFL OCT), and OCT-angiography (OCT-A) for evaluation of the retinal layer thickness and vessel density (VD) parameters. A multifocal visual evoked potential (mfVEP) test, including amplitude and latency, was used to assess the visual pathway function. Finally, cognitive function was evaluated using a battery of neuropsychological tests. OCT-A images were analysed in ImageJ to quantify VD in the superficial and deep vascular plexus and the size of the foveal avascular zone (FAZ). The relationship between carriers of APOE ε4 allele and these ocular parameters was analysed using generalised estimating equation (GEE) models and data adjusted for age, sex and inter-eye differences as within-subject variables (

resultsTwenty-four participants were APOE ε4 carriers. Temporal RNFL thickness was decreased in APOE ε4 carriers (

conclusionsRetinal abnormalities were present in participants with increased genetic risk of dementia due to presence of the ε4 allele. These findings provide preliminary evidence for their potential role in the diagnosis of dementia.

Indexed as

APOEdementiaMRIOCTretina

Identifiers

PMID37834863
PMCPMC10573915
OpenAlexW4387100839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.