Evidence map›Paper›PMID 37834849›Full record

ArticleJournal of clinical medicine2023

Dialysis Patients Respond Adequately to Influenza Vaccination Irrespective of Dialysis Modality and Chronic Inflammation.

Christos Pleros, Konstantinos Adamidis, Konstantia Kantartzi, Ioannis Griveas, Ismini Baltsavia, Aristides Moustakas, Antonios Kalliaropoulos, Evaggelia Fraggedaki, Christina Petra, Nikolaos Damianakis and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christos PlerosNephrology Department, University Hospital of Heraklion, 71500 Heraklion, Greece.
Konstantinos AdamidisDialysis Unit Bionephros, 18345 Athens, Greece.
Konstantia KantartziNephrology Department, University Hospital of Alexandroupoli, 68100 Alexandroupoli, Greece.
Ioannis GriveasNephrology Department, 417 Army Share Fund Hospital of Athens, 11521 Athens, Greece.
Ismini BaltsaviaLaboratory of Computational Biology, Division of Basic Sciences, Medical School, University of Crete, 71500 Heraklion, Greece.ORCID 0000-0002-1735-4468
Aristides MoustakasInfometrics Data Analytics Ltd., 128 City Road, London EC1V 2NX, UK.ORCID 0000-0002-6334-747X
Antonios KalliaropoulosNational Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, 11521 Athens, Greece.
Evaggelia FraggedakiNephroxenia Dialysis Unit, 73100 Chania, Greece.
Christina PetraVenizeleio-Pananeio General Hospital of Heraklion, 71409 Heraklion, Greece.
Nikolaos DamianakisNephrology Department, General Hospital of Chania, 73300 Chania, Greece.
Andreas MentisNational Influenza Reference Laboratory for Southern Greece, Hellenic Pasteur Institute, 11521 Athens, Greece.
Eleni DrosatakiNephrology Department, University Hospital of Heraklion, 71500 Heraklion, Greece.
Ioannis PetrakisNephrology Department, University Hospital of Heraklion, 71500 Heraklion, Greece.ORCID 0000-0002-0095-9823
Ploumis PassadakisNephrology Department, University Hospital of Alexandroupoli, 68100 Alexandroupoli, Greece.
Periklis PanagopoulosDepartment of Infectious Diseases, Second University Department of Internal Medicine, University Hospital of Alexandroupoli, Democritus University of Thrace, 68100 Alexandroupoli, Greece.
Kostas StylianouNephrology Department, University Hospital of Heraklion, 71500 Heraklion, Greece.ORCID 0000-0003-3678-9421
Stylianos PanagoutsosNephrology Department, University Hospital of Alexandroupoli, 68100 Alexandroupoli, Greece.

Funding

Hellenic Society of Nephrology 2020
6 · The paper itself

Abstract

(1) Background: Chronic inflammation and suboptimal immune responses to vaccinations are considered to be aspects of immune dysregulation in patients that are undergoing dialysis. The present study aimed to evaluate immune responses in hemodialysis (HD) and online hemodiafiltration (OL-HDF) patients to a seasonal inactivated quadrivalent influenza vaccine (IQIV). (2) Methods: We enrolled 172 chronic dialysis patients (87 on HD and 85 on OL-HDF) and 18 control subjects without chronic kidney disease in a prospective, cross-sectional cohort study. Participants were vaccinated with a seasonal IQIV, and antibody titers using the hemagglutination inhibition (HI) assay were determined before vaccination (month 0) and 1, 3, and 6 months thereafter. Demographics and inflammatory markers (CRP, IL-6, IL-1β) were recorded at month 0. The primary endpoints were the rates of seroresponse (SR), defined as a four-fold increase in the HI titer, and seroprotection (SP), defined as HI titer ≥ 1/40 throughout the study period. Statistical analyses were conducted in R (version 3.6.3) statistical software. The differences between groups were analyzed using chi-square and

Indexed as

chronic inflammationdialysishemodiafiltrationimmune responseinfluenza vaccination

Identifiers

PMID37834849
PMCPMC10573409

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.