Evidence map›Paper›PMID 37834840›Full record

ArticleJournal of clinical medicine2023

Multimodal Therapy with Consolidating Haploidentical Stem Cell Transplantation and Dinutuximab Beta for Patients with High-Risk Neuroblastoma and Central Nervous System Relapse.

Tim Flaadt, Martin Ebinger, Malin Schreiber, Ruth L Ladenstein, Thorsten Simon, Holger N Lode, Barbara Hero, Martin U Schuhmann, Jürgen Schäfer, Frank Paulsen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Immunotherapeutic Strategies Targeting GD2-Expressing Malignancies.Advances in experimental medicine and biology · 2026
    Review
  2. Theranostics for Neuroblastoma: Making Molecular Radiotherapy Work Better.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  3. Neuroblastoma-A Review of Combination Immunotherapy.International journal of molecular sciences · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Tim FlaadtDepartment of Hematology and Oncology, University Children's Hospital, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0002-2729-9941
Martin EbingerDepartment of Hematology and Oncology, University Children's Hospital, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0002-4229-8058
Malin SchreiberDepartment of Hematology and Oncology, University Children's Hospital, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.ORCID 0009-0002-4057-9179
Ruth L LadensteinDepartment of Pediatrics, St Anna Children's Hospital, Medical University, 1090 Vienna, Austria.
Thorsten SimonDepartment of Pediatric Oncology and Hematology, University Hospital, University of Cologne, 50937 Köln, Germany.ORCID 0000-0002-3425-8451
Holger N LodeDepartment of Pediatric Hematology and Oncology, University Medicine Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-1201-208X
Barbara HeroDepartment of Pediatric Oncology and Hematology, University Hospital, University of Cologne, 50937 Köln, Germany.
Martin U SchuhmannSection of Pediatric Neurosurgery, Department of Neurosurgery, University Hospital of Tuebingen, 72076 Tuebingen, Germany.
Jürgen SchäferDepartment for Diagnostic and Interventional Radiology, University Hospital, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0003-3279-8726
Frank PaulsenDepartment of Radiation Oncology, University Hospital Tuebingen, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0001-8836-528X
Beate TimmermannDepartment of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen (WPE), West German Cancer Center (WTZ), German Cancer Consortium (DKTK), 45147 Essen, Germany.
Angelika EggertDepartment of Pediatric Oncology/Hematology, Charité-Universitaetsmedizin Berlin, 13353 Berlin, Germany.ORCID 0000-0003-3476-8184
Peter LangDepartment of Hematology and Oncology, University Children's Hospital, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.ORCID 0000-0001-7737-2142
University Children's Hospital Tübingen · DEUniversity of Tübingen · DEUniversity of Cologne · DECharité - Universitätsmedizin Berlin · DEDeutschen Konsortium für Translationale Krebsforschung · DESt Anna Children's Hospital · ATUniversitätsmedizin Greifswald · DE

Funding

EUSA Pharma NA
6 · The paper itself

Abstract

Despite highly intensive multimodality treatment regimens, the prognosis of patients with high-risk neuroblastoma (HRNB) and central nervous system (CNS) relapse remains poor. We retrospectively reviewed data from 13 patients with HRNB and CNS relapse who received multimodal therapy with consolidating haploidentical stem cell transplantation (haplo-SCT) followed by dinutuximab beta ± subcutaneous interleukin-2 (scIL-2). Following individual relapse treatment, patients aged 1-21 years underwent haplo-SCT with T/B-cell-depleted grafts followed by dinutuximab beta 20 mg/m

Indexed as

central nervous systemdinutuximab betaneuroblastomarecurrence

Identifiers

PMID37834840
PMCPMC10573405
OpenAlexW4387053627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.