Evidence map›Paper›PMID 37834476›Full record

ArticleInternational journal of molecular sciences2023

The MADF-BESS Protein CP60 Is Recruited to Insulators via CP190 and Has Redundant Functions in

Larisa Melnikova, Varvara Molodina, Valentin Babosha, Margarita Kostyuchenko, Pavel Georgiev, Anton Golovnin

Open access · goldAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Larisa MelnikovaDepartment of Drosophila Molecular Genetics, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, Moscow 119334, Russia.
Varvara MolodinaDepartment of Drosophila Molecular Genetics, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, Moscow 119334, Russia.
Valentin BaboshaDepartment of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, Moscow 119334, Russia.ORCID 0000-0003-0402-3915
Margarita KostyuchenkoDepartment of Drosophila Molecular Genetics, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, Moscow 119334, Russia.
Pavel GeorgievDepartment of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, Moscow 119334, Russia.ORCID 0000-0002-6509-3194
Anton GolovninDepartment of Drosophila Molecular Genetics, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, Moscow 119334, Russia.
Institute of Gene Biology · RU

Funding

Ministry of Science and Higher Education of Russian Federation 075-15-2019-1661Russian Science Foundation 21-14-00205
6 · The paper itself

Abstract

Drosophila CP190 and CP60 are transcription factors that are associated with centrosomes during mitosis. CP190 is an essential transcription factor and preferentially binds to housekeeping gene promoters and insulators through interactions with architectural proteins, including Su(Hw) and dCTCF. CP60 belongs to a family of transcription factors that contain the N-terminal MADF domain and the C-terminal BESS domain, which is characterized by the ability to homodimerize. In this study, we show that the conserved CP60 region adjacent to MADF is responsible for interacting with CP190. In contrast to the well-characterized MADF-BESS transcriptional activator Adf-1, CP60 is recruited to most chromatin sites through its interaction with CP190, and the MADF domain is likely involved in protein-protein interactions but not in DNA binding. The deletion of the

Indexed as

DrosophilaDrosophila ProteinsAnimalsCell Cycle ProteinsDrosophila melanogasterMicrotubule-Associated ProteinsNuclear ProteinsProtein BindingTranscription FactorsCell Cycle ProteinsCP190 protein, DrosophilaDrosophila ProteinsMap60 protein, DrosophilaMicrotubule-Associated ProteinsNuclear ProteinsTranscription Factorsarchitectural C2H2 proteinsgypsyhousekeeping genesinsulatorMADF-BESS transcriptional factorsSu(Hw)

Identifiers

PMID37834476
PMCPMC10573801
OpenAlexW4387461124

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.