Evidence map›Paper›PMID 37834415›Full record

ArticleInternational journal of molecular sciences2023

Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria.

Katrina Browne, Rajesh Kuppusamy, William R Walsh, David StC Black, Mark D P Willcox, Naresh Kumar, Renxun Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Antimicrobial activity of a short guanidine mimic immobilised on contact lenses.Journal of materials science. Materials in medicine · 2026
    Article
  7. Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Katrina BrowneSchool of Chemistry, University of New South Wales (UNSW) Sydney, Sydney 2052, Australia.
Rajesh KuppusamySchool of Chemistry, University of New South Wales (UNSW) Sydney, Sydney 2052, Australia.ORCID 0000-0001-9844-5064
William R WalshSurgical and Orthopaedic Research Laboratories (SORL), Prince of Wales Clinical School, Prince of Wales Hospital, University of New South Wales (UNSW), Randwick 2031, Australia.ORCID 0000-0002-5023-6148
David StC BlackSchool of Chemistry, University of New South Wales (UNSW) Sydney, Sydney 2052, Australia.ORCID 0000-0001-9300-4737
Mark D P WillcoxSchool of Optometry and Vision Science, University of New South Wales (UNSW) Sydney, Sydney 2052, Australia.ORCID 0000-0003-3842-7563
Naresh KumarSchool of Chemistry, University of New South Wales (UNSW) Sydney, Sydney 2052, Australia.ORCID 0000-0002-0951-9621
Renxun ChenSchool of Chemistry, University of New South Wales (UNSW) Sydney, Sydney 2052, Australia.ORCID 0000-0003-0828-9980
UNSW Sydney · AU

Funding

National Health and Medical Research Council APP1183597
6 · The paper itself

Abstract

Bacteria readily acquire resistance to traditional antibiotics, resulting in pan-resistant strains with no available treatment. Antimicrobial resistance is a global challenge and without the development of effective antimicrobials, the foundation of modern medicine is at risk. Combination therapies such as antibiotic-antibiotic and antibiotic-adjuvant combinations are strategies used to combat antibiotic resistance. Current research focuses on antimicrobial peptidomimetics as adjuvant compounds, due to their promising activity against antibiotic-resistant bacteria. Here, for the first time we demonstrate that antibiotic-peptidomimetic combinations mitigate the development of antibiotic resistance in

Indexed as

Anti-Infective AgentsPeptidomimeticsAnti-Bacterial AgentsBacteriaCiprofloxacinGentamicinsGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsPseudomonas aeruginosaStaphylococcusStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsCiprofloxacinGentamicinsPeptidomimeticsantibiotic resistanceantibioticsantimicrobial peptidespeptidomimetics

Identifiers

PMID37834415
PMCPMC10573972
OpenAlexW4387422728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.