Evidence map›Paper›PMID 37834394›Full record

ArticleInternational journal of molecular sciences2023

Identification of NCAPG as an Essential Gene for Neuroblastoma Employing CRISPR-Cas9 Screening Database and Experimental Verification.

Yubin Jia, Jiaxing Yang, Yankun Chen, Yun Liu, Yan Jin, Chaoyu Wang, Baocheng Gong, Qiang Zhao

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yubin JiaDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Jiaxing YangDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Yankun ChenDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Yun LiuDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Yan JinDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Chaoyu WangDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Baocheng GongDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Qiang ZhaoDepartment of Pediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Tianjin Medical University Cancer Institute and Hospital · CN

Funding

National Key Research and Development Program of China 2018YFC1313000National Key Research and Development Program of China 2018YFC1313001Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-009A
6 · The paper itself

Abstract

Neuroblastoma is the most common extracranial solid tumor in children. Patients with neuroblastoma have a poor prognosis. The development of therapy targets and the ability to predict prognosis will be enhanced through further exploration of the genetically related genes of neuroblastoma. The present investigation utilized CRISPR-Cas9 genome-wide screening based on the DepMap database to determine essential genes for neuroblastoma cells' continued survival. WGCNA analysis was used to determine the progression-related genes, and a prognostic signature was constructed. The signature gene,

Indexed as

CRISPR-Cas SystemsNeuroblastomaCell Cycle ProteinsCell Line, TumorChildGenes, EssentialHumansCell Cycle ProteinsNCAPG protein, humanCRISPR-Cas9DepmapNCAPGneuroblastomaproliferationrisk signature

Identifiers

PMID37834394
PMCPMC10573393
OpenAlexW4387401106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.