Evidence map›Paper›PMID 37834342›Full record

ArticleInternational journal of molecular sciences2023

β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure-Activity Relationships and Antiallodynic Activity.

Cristina Martín-Escura, M Ángeles Bonache, Jessy A Medina, Alicia Medina-Peris, Jorge De Andrés-López, Sara González-Rodríguez, Sara Kerselaers, Gregorio Fernández-Ballester, Thomas Voets, Antonio Ferrer-Montiel and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Cristina Martín-EscuraInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.
M Ángeles BonacheInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.ORCID 0000-0002-4922-5345
Jessy A MedinaInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.
Alicia Medina-PerisIDiBE, Universidad Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0002-8035-0179
Jorge De Andrés-LópezIDiBE, Universidad Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0001-7797-4688
Sara González-RodríguezIDiBE, Universidad Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0001-6906-8108
Sara KerselaersLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain and Disease Research, KU Leuven, Herestraat 49 Box 802, 3000 Leuven, Belgium.
Gregorio Fernández-BallesterIDiBE, Universidad Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0002-5412-8611
Thomas VoetsLaboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain and Disease Research, KU Leuven, Herestraat 49 Box 802, 3000 Leuven, Belgium.ORCID 0000-0001-5526-5821
Antonio Ferrer-MontielIDiBE, Universidad Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0002-2973-6607
Asia Fernández-CarvajalIDiBE, Universidad Miguel Hernández, 03202 Elche, Spain.ORCID 0000-0003-2741-1427
Rosario González-MuñizInstituto de Química Médica (IQM-CSIC), 28006 Madrid, Spain.ORCID 0000-0001-8833-4328
Universitat de Miguel Hernández d'Elx · ESInstituto de Química Médica · ESVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

PSYCHOSOCIAL TREATMENTS FOR COCAINE ABUSEU01DA007673 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THASE, MICHAEL E · 1991 to 1997
–
PSYCHOSOCIAL TREATMENTS FOR COCAINE ABUSEU18DA007673 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THASE, MICHAEL E · 1991 to 1994
–
Comunidad de Madrid IND2017/BMD7673Generalitat Valenciana PROMETEO/2021/031Spanish Ministerio de Ciencia e Innovación (cofunded by FEDER, una manera de hacer Europa) RTI2018-097189-B-C21, RTI2018-097189-B-C22, PID2021-126423OB-C21 and PID2021-126423OB-C22
6 · The paper itself

Abstract

The protein transient receptor potential melastatin type 8 (TRPM8), a non-selective, calcium (Ca

Indexed as

Transient Receptor Potential ChannelsTRPM Cation ChannelsAnimalsAntigensbeta-LactamsMicePhenylalanineStructure-Activity RelationshipAntigensbeta-LactamsPhenylalaninephenylalaninolTransient Receptor Potential ChannelsTRPM8 protein, mouseTRPM Cation Channelsantagonistsantinociceptive activitydockingTRPM8 channelβ-lactams

Identifiers

PMID37834342
PMCPMC10573892
OpenAlexW4387343908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.