Evidence map›Paper›PMID 37834072›Full record

ArticleInternational journal of molecular sciences2023

Role of Tyrosine Nitrosylation in Stress-Induced Major Depressive Disorder: Mechanisms and Implications.

Gregory C Wilson, Simone Keitsch, Matthias Soddemann, Barbara Wilker, Michael J Edwards, Erich Gulbins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Gregory C WilsonDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Simone KeitschInstitute of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Matthias SoddemannInstitute of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Barbara WilkerInstitute of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Michael J EdwardsInstitute of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Erich GulbinsDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Institute of Molecular Biology · DEUniversity of Cincinnati Medical Center · USUniversity of Duisburg-Essen · DE

Funding

Deutsche Forschungsgemeinschaft Deutsche Forschungsgemeinsschaft DFG Gu 335/29-3 and Gu 335/42-1
6 · The paper itself

Abstract

Major depressive disorder (MDD) has a lifetime prevalence of approximately 10% and is one of the most common diseases worldwide. Although many pathogenetic mechanisms of MDD have been proposed, molecular details and a unifying hypothesis of the pathogenesis of MDD remain to be defined. Here, we investigated whether tyrosine nitrosylation, which is caused by reaction of the C-atom 3 of the tyrosine phenol ring with peroxynitrate (ONOO

Indexed as

Major Depressive DisorderAnimalsAntidepressive AgentsFluoxetineGlucocorticoidsHippocampusMiceTyrosineAntidepressive AgentsFluoxetineGlucocorticoidsTyrosineantidepressantscatalaseceramidehippocampusmajor depressive disorderneuroinflammationneuroplasticityperoxidasesphosphatidic acidtyrosine nitrosylation

Identifiers

PMID37834072
PMCPMC10572173
OpenAlexW4387105596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.