Evidence map›Paper›PMID 37834037›Full record

ArticleInternational journal of molecular sciences2023

Synthesis and Biological Activity of a New Indenoisoquinoline Copper Derivative as a Topoisomerase I Inhibitor.

Caroline Molinaro, Nathalie Wambang, Sylvain Pellegrini, Natacha Henry, Marc F Lensink, Emmanuelle Germain, Till Bousquet, Jérôme de Ruyck, Katia Cailliau, Lydie Pélinski and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caroline MolinaroUniv. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.ORCID 0000-0002-7002-5030
Nathalie WambangUniv. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France.
Sylvain PellegriniUniv. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France.
Natacha HenryUniv. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France.
Marc F LensinkUniv. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.ORCID 0000-0003-3957-9470
Emmanuelle GermainUniv. Lille, Inserm U1003-PHYCEL-Physiologie Cellulaire, F-59000 Lille, France.
Till BousquetUniv. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France.
Jérôme de RuyckUniv. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.ORCID 0000-0003-4397-1870
Katia CailliauUniv. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.
Lydie PélinskiUniv. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France.ORCID 0000-0002-5691-7550
Alain MartoriatiUniv. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.ORCID 0000-0002-5684-1728

Funding

Ligue Contre le Cancer, Comités Nord et Aisne 2022Ligue Contre le Cancer, Comités Pas de Calais 2015
6 · The paper itself

Abstract

Topoisomerases are interesting targets in cancer chemotherapy. Here, we describe the design and synthesis of a novel copper(II) indenoisoquinoline complex,

Indexed as

Antineoplastic AgentsTopoisomerase I InhibitorsApoptosisCell Line, TumorCell ProliferationCopperDNADrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipTopoisomerase InhibitorsAntineoplastic AgentsCopperDNATopoisomerase I InhibitorsTopoisomerase Inhibitorsadenocarcinomacopper(II) complexDNA intercalationindenoisoquinolinemolecular modelingtopoisomerase I

Identifiers

PMID37834037
PMCPMC10572568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.