Evidence map›Paper›PMID 37834031›Full record

ArticleInternational journal of molecular sciences2023

The Local Anaesthetic Procaine Prodrugs ProcCluster

Clio Häring, Johannes Jungwirth, Josefine Schroeder, Bettina Löffler, Beatrice Engert, Christina Ehrhardt

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Advancing influenza virus treatment:Materials today. Bio · 2025
    Article
  2. The Procaine-Based ProcClusterInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. ProcClusterFrontiers in microbiology · 2024
    Article
  5. ProcCluster® and procaine hydrochloride inhibit the growth ofFrontiers in cellular and infection microbiology · 2024
    Article
  6. COVID-19 Pandemic: Therapeutic Strategies and Vaccines.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clio HäringSection of Experimental Virology, Institute of Medical Microbiology, Center for Molecular Biomedicine (CMB), Jena University Hospital, 07745 Jena, Germany.
Johannes JungwirthSection of Experimental Virology, Institute of Medical Microbiology, Center for Molecular Biomedicine (CMB), Jena University Hospital, 07745 Jena, Germany.
Josefine SchroederSection of Experimental Virology, Institute of Medical Microbiology, Center for Molecular Biomedicine (CMB), Jena University Hospital, 07745 Jena, Germany.
Bettina LöfflerInstitute of Medical Microbiology, Jena University Hospital, 07747 Jena, Germany.
Beatrice EngertInflamed Pharma GmbH, 07745 Jena, Germany.
Christina EhrhardtSection of Experimental Virology, Institute of Medical Microbiology, Center for Molecular Biomedicine (CMB), Jena University Hospital, 07745 Jena, Germany.ORCID 0000-0002-8879-6087

Funding

inflamed pharma GmbH DD 0144-20Thüringer Aufbaubank VF0013/FE 9037Thüringer Aufbaubank VF0013/FE 9038
6 · The paper itself

Abstract

As vaccination efforts against SARS-CoV-2 progress in many countries, there is still an urgent need for efficient antiviral treatment strategies for those with severer disease courses, and lately, considerable efforts have been undertaken to repurpose existing drugs as antivirals. The local anaesthetic procaine has been investigated for antiviral properties against several viruses over the past decades. Here, we present data on the inhibitory effect of the procaine prodrugs ProcCluster

Indexed as

COVID-19ProdrugsAnesthetics, LocalAnimalsAntiviral AgentsChlorocebus aethiopsProcaineSARS-CoV-2Vero CellsVirus ReplicationAnesthetics, LocalAntiviral AgentsProcaineProdrugsantiviralslocal anaestheticsprocaineSARS-CoV-2

Identifiers

PMID37834031
PMCPMC10572566

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.