Evidence map›Paper›PMID 37834027›Full record

ArticleInternational journal of molecular sciences2023

LQFM289: Electrochemical and Computational Studies of a New Trimetozine Analogue for Anxiety Treatment.

Jhon K A Pereira, André G C Costa, Edson S B Rodrigues, Isaac Y L Macêdo, Marx O A Pereira, Ricardo Menegatti, Severino C B de Oliveira, Freddy Guimarães, Luciano M Lião, José R Sabino and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jhon K A PereiraFaculty of Pharmacy, Federal University of Goias, Goiânia 74690-970, Brazil.
André G C CostaFaculty of Pharmacy, Federal University of Goias, Goiânia 74690-970, Brazil.
Edson S B RodriguesFaculty of Pharmacy, Federal University of Goias, Goiânia 74690-970, Brazil.ORCID 0000-0003-2965-0421
Isaac Y L MacêdoFaculty of Pharmacy, Federal University of Goias, Goiânia 74690-970, Brazil.ORCID 0000-0002-6043-5343
Marx O A PereiraFaculty of Pharmacy, Federal University of Goias, Goiânia 74690-970, Brazil.ORCID 0000-0003-4067-3931
Ricardo MenegattiFaculty of Pharmacy, Federal University of Goias, Goiânia 74690-970, Brazil.ORCID 0000-0001-5044-9234
Severino C B de OliveiraDepartament of Chemistry, Federal Rural University of Pernambuco, Recife 52171-900, Brazil.ORCID 0000-0003-3968-5046
Freddy GuimarãesInstitute of Chemistry, Federal University of Goias, Goiânia 74690-970, Brazil.
Luciano M LiãoInstitute of Chemistry, Federal University of Goias, Goiânia 74690-970, Brazil.ORCID 0000-0001-9985-2980
José R SabinoInstitute of Physics, Federal University of Goias, Goiânia 74690-970, Brazil.
Eric de S GilFaculty of Pharmacy, Federal University of Goias, Goiânia 74690-970, Brazil.ORCID 0000-0001-9161-0127
Universidade Federal de Goiás · BRUniversidade Federal Rural de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study employs electrochemical and Density Functional Theory (DFT) calculation approaches to investigate the potential of a novel analogue of trimetozine (TMZ) antioxidant profile. The correlation between oxidative stress and psychological disorders indicates that antioxidants may be an effective alternative treatment option. Butylatedhydroxytoluene (BHT) is a synthetic antioxidant widely used in industry. The BHT-TMZ compound derived from molecular hybridization, known as LQFM289, has shown promising results in early trials, and this study aims to elucidate its electrochemical properties to further support its potential as a therapeutic agent. The electrochemical behavior of LQFM289 was investigated using voltammetry and a mechanism for the redox process was proposed based on the compound's behavior. LQFM289 exhibits two distinct oxidation peaks: the first peak,

Indexed as

AntioxidantsMorpholinesAnxietyOxidation-ReductionAntioxidantsMorpholinestrimetozineantioxidantanxietybutylhydroxytoluenedrug discoveryoxidation mechanism

Identifiers

PMID37834027
PMCPMC10572256
OpenAlexW4387048801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.