Evidence map›Paper›PMID 37833753›Full record

ArticleBMC oral health2023

Identification of the causal relationship between sleep quality, insomnia, and oral ulcers.

Qianxi Liu, Jiongke Wang, Tiannan Liu, Xin Zeng, Xuefeng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qianxi LiuState Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences, Sichuan University, 3rd Section of Ren Min Nan Rd, Chengdu, 610041, Sichuan, P. R. China.
Jiongke WangState Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences, Sichuan University, 3rd Section of Ren Min Nan Rd, Chengdu, 610041, Sichuan, P. R. China.
Tiannan LiuState Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences, Sichuan University, 3rd Section of Ren Min Nan Rd, Chengdu, 610041, Sichuan, P. R. China.
Xin ZengState Key Laboratory of Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences, Sichuan University, 3rd Section of Ren Min Nan Rd, Chengdu, 610041, Sichuan, P. R. China. zengxin@scu.edu.cn.
Xuefeng ZhangEmergency Department, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Chinese Academy of Medical Sciences, Sichuan University, Chengdu, 610041, Sichuan, P. R. China. zhangxuefeng1990@scu.edu.cn.
Sichuan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple epidemiological studies have posited a potential association between sleep quality and the risk of oral diseases, yet the resulting conclusions have remained contentious, and the presence of a causal link remains equivocal. In this study, we aimed to investigate the causal relationship between sleep duration, insomnia, and common oral diseases.

methodsWe utilized genetic correlation and two-sample Mendelian randomization analyses based on summary statistics from genome-wide association studies of sleep duration (N = 460,099), insomnia (N = 462,341), mouth ulcer (N = 385,026), oral cavity cancer (N = 4,151), and periodontal disease (N = 527,652).

resultsOur results revealed a negative genetic correlation between sleep duration and mouth ulcer (genetic correlation: -0.09, P = 0.007), while a positive genetic correlation between insomnia and mouth ulcer was observed (genetic correlation: 0.18, P = 2.51E-06). Furthermore, we demonstrated that longer sleep duration is significantly associated with a reduced risk of mouth ulcers (OR: 0.67, 95% CI: 0.54-0.83, P = 2.84E-04), whereas insomnia is nominally associated with an increased risk of mouth ulcers (OR: 1.40, 95% CI: 1.01-1.95, P = 0.044). In contrast, no significant association was detected between sleep quality and periodontal disease or oral cavity cancer.

conclusionsThis work provides robust evidence to support the notion that enhanced sleep quality may confer a decreased risk of oral ulcers, thereby bearing considerable clinical relevance.

Indexed as

NeoplasmsOral UlcerPeriodontal DiseasesSleep Initiation and Maintenance DisordersGenome-Wide Association StudyHumansPolymorphism, Single NucleotideSleepSleep QualityGenetic correlationInsomniaMendelian randomizationMouth ulcerSleep duration

Identifiers

PMID37833753
PMCPMC10571295
OpenAlexW4387616359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.