SynthesisJournal of cardiothoracic surgery2023
Hemolysis and cardiopulmonary bypass: meta-analysis and systematic review of contributing factors.
Synthesis in Journal of cardiothoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.British journal of anaesthesia · 2025Guideline
- Clinical evaluation of SafeCECThe journal of extra-corporeal technology · 2025Trial
- Early postoperative "grey zone" gradients following aortic valve replacement surgery: the clinical course and mechanical stress biomarker profile.Surgery today · 2026Observational
- Association of Previous COVID-19 Infection and Preoperative Haemoglobin with Transfusion Burden and Early Postoperative Outcomes Following Cardiac Surgery with Cardiopulmonary Bypass.Journal of clinical medicine · 2026Article
- From Early Models to Emerging Trends: The Evolution of Computational Hemolysis Prediction.Annals of biomedical engineering · 2026Review
- Iron Compartmentalisation and Vascular Endothelial Cell Dysfunction.Antioxidants (Basel, Switzerland) · 2026Review
- Comparative Analysis of Pressure Drop (Δp): Hemodynamic Performance of Three Commercial Oxygenators During Cardiopulmonary Bypass.Artificial organs · 2026Observational
- The Impact of Cardiopulmonary Bypass on the Structure and Mechanics of Red Blood Cells: Pilot Study.Journal of clinical medicine · 2026Article
- Advanced Metabolic-Guided Perfusion Concepts in an Obese Patient Undergoing Cardiac Surgery: A Case Report.Cureus · 2025Article
- Hydrodynamic-derived centrifugal blood pump design for stable-low-flow-rate rate performance: from surface to structure.Bioactive materials · 2025Article
- Article
- Kidney Injury Following Cardiac Surgery: A Review of Our Current Understanding.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Review
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- A clinical comparison of the effects of six disposable cardiopulmonary bypass circuits on bleeding and coagulation: a quality assurance project.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Article
- Assessing the Predictive Impact of Preoperative Lactate Dehydrogenase to Albumin Ratio on Outcomes Following Coronary Artery Bypass Graft Surgery.Journal of clinical medicine · 2025Article
- A Tale of Triumph: Overcoming Challenges in Surgical ASD Closure for a Patient with Warm AIHA.Cardiovascular & hematological disorders drug targets · 2025Article
- PreliminaryFrontiers in medical technology · 2025Article
- Cardiac surgery-associated acute kidney injury in cardiopulmonary bypass: a focus on sex differences and preventive strategies.American journal of physiology. Renal physiology · 2024Review
- Hemolysis during open heart surgery in patients with hereditary spherocytosis - systematic review of the literature and case study.Perioperative medicine (London, England) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of cardiopulmonary bypass (CPB) is almost inevitable in cardiac surgery. However, it can cause complications, including hemolysis. Until now, there have not been any standards for reducing hemolysis from CPB. Therefore, this systematic review was conducted to determine the factors that increase or reduce hemolysis in the use of CPB.
methodsKeywords Earches (cardiac surgery AND cardiopulmonary bypass AND hemolysis) were done on PubMed databases and Cochrane CENTRAL from 1990-2021 for published randomized controlled trials (RCTs) that studied interventions on CPB, in cardiac surgery patients, and measured hemolysis as one of the outcomes. Studies involving patients with preoperative hematological disorders, prosthetic valves, preoperative use of intra-aortic balloon pumps and extracorporeal circulation, emergency and minimally invasive surgery are excluded
resultsThe search yielded 64 studies that met the inclusion criteria, which involved a total of 3,434 patients. The most common surgery was coronary revascularization (75%). Out of 64 studies, 33 divided into 7 analyses. Remaining 31 studies were synthesized qualitatively. Significant decreases were found in centrifugal vs roller pumps for PFHb (p = 0.0006) and Hp (p < 0.0001) outcomes, separated vs combined suctioned blood (p = 0.003), CPB alternatives vs conventional CPB (p < 0.0001), and mini extracorporeal circulation (MiniECC) vs conventional CPB for LDH (p = 0.0008). Significant increases were found in pulsatility (p = 0.03) and vacuum-assisted venous drainage (VAVD) vs gravity-assisted venous drainage (GAVD) (p = 0.002).
conclusionThe review shows that hemolysis could be caused by several factors and efforts have been made to reduce it, combining significant efforts could be beneficial. However, this review has limitations, such as heterogeneity due to no standards available for conducting CPB. Therefore, further research with standardized guidelines for CPB is needed to yield more comparable studies. Meta-analyses with more specific parameters should be done to minimize heterogeneity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.