ArticleBMC geriatrics2023
Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of exercise modalities on cognitive and muscle function in older adults with cognitive impairment: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Longitudinal dynamic relationships among social frailty, depression, cognitive function, and physical frailty in community-dwelling older adults: A random intercept cross-lagged panel model study.International journal of nursing studies advances · 2026Article
- Association of physical frailty, functional dependence, dysphagia, and depression with mild cognitive impairment in hospitalized older adults.Frontiers in medicine · 2026Article
- Bidirectional relationships between disability and cognitive decline: a 6-year longitudinal study.BMC geriatrics · 2025Article
- Association of multimorbidity patterns and order of physical frailty and cognitive impairment occurrence: a prospective cohort study.Age and ageing · 2025Article
- Indoor ventilation frequency and cognitive function among Chinese old adults: the multiple mediation effect of anxiety and self-rated health.BMC geriatrics · 2025Article
- Frailty as a mediator between sleep quality and cognitive impairment among the rural older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Association between pre-stroke frailty status and post-stroke cognitive impairment in patients with acute large artery atherosclerotic cerebral infarction.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer.Frontiers in aging neuroscience · 2025Article
- Factors associated with social participation among community-dwelling frail older adults in Japan: a cross-sectional study.BMC geriatrics · 2024Article
- Profiles of physical frailty, social frailty, and cognitive impairment among older adults in rural areas of China: a latent profile analysis.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the association of longitudinal dynamics between cognitive function and frailty in Chinese older adults. The temporal sequences between cognitive function and frailty remains unclear. Our study investigates this directionality association using longitudinal data.
methodsLatent growth and multivariate latent growth models were employed to examine dynamics of cognition and frailty and their association among 2824 older adults in China. Cross-lagged panel analyses were used to assess the temporal sequences between frailty and cognition. The relation between cognitive domains and frailty was also examined using aforementioned methods.
resultsCognitive function was negatively associated with frailty status. Higher initial level of cognition indicated lower baseline level (β=-0.175, P < 0.001) and change rate (β=-0.041, P = 0.002) of frailty. We observed a reciprocal association between frailty and cognitive function rather than a unidirectional causal relationship. The initial cognitive performance for all components were negatively associated with baseline (β ranged between - 0.098 to -0.023) and change rate (β ranged between - 0.007 to -0.024) of frail status. No consistent associations between change rate of cognitive components and either initial level or change rate of frailty were detected.
conclusionsOur study detected a reciprocal association between cognition and frailty rather than a unidirectional causal relationship. Our results also revealed different connections between cognitive performance and frailty across diverse cognitive domains.
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