Evidence map›Paper›PMID 37833611›Full record

ArticleDoklady. Biochemistry and biophysics2023

Approbation of a New Model of Secondary Damage after Traumatic Brain Injury Based on Reprogrammed Rat Embryo Fibroblasts.

E B Rykunova, M A Mikeladze, I A Utepova, O N Chupakhin, I V Guzhova, V F Lazarev

Abstract read
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E B RykunovaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
M A MikeladzeInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
I A UtepovaUral Federal University, Yekaterinburg, Russia.
O N ChupakhinUral Federal University, Yekaterinburg, Russia.
I V GuzhovaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
V F LazarevInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia. lazarev@incras.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic effect of inducers of the synthesis of chaperones from the classes of pyrrolylazines and indolylazines, which have neuroprotective properties.

Indexed as

Brain InjuriesBrain Injuries, TraumaticAnimalsNeuronsRatscerebrospinal fluidchaperonesHsp70pyrrolylazine and indolylazine derivativessecondary injuriestraumatic brain injury

Identifiers

PMID37833611
PMCPMC10575796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.