Evidence map›Paper›PMID 37833582›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2023

Combined Gamma-Rays and Carbon-12 Nuclei Irradiation Modulates Brain Chemokine and Cytokine Production and Improves Spatial Learning in Tau P301S, but not 5xFAD Mouse Line.

V S Kokhan, M S Nesterov, A I Levashova

Abstract read
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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

V S KokhanSerbsky Federal Medical Research Centre for Psychiatry and Narcology, Moscow, Russia. viktor_kohan@hotmail.com.
M S NesterovScientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia, settlement Svetlye Gory, Moscow Region, Russia.
A I LevashovaScientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia, settlement Svetlye Gory, Moscow Region, Russia.
Federal Medical-Biological Agency · RUFederal Medical Research Centre for Psychiatry and Narcology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier we showed the pro-cognitive effect of low doses of combined irradiation (including heavy charged particles) on Wistar rats. In the present work we studied the effect of irradiation (gamma-rays, 0.24 Gy; carbon-12, 0.18 Gy, 400 MeV/nucleon) on the course of neurodegenerative process using Tau P301S and 5xFAD transgenic mice lines, experimental models of Alzheimer's disease. Irradiation led to an increase in pro- and anti-inflammatory cytokines and chemokines (IL-2, IL-6, IL-10, KC) in Tau P301S mice, but not in 5xFAD. At the same time, only the Tau P301S line was found to exhibit radiation-induced improvement in spatial learning.

Indexed as

Spatial Learningtau ProteinsAnimalsBrainChemokinesDisease Models, AnimalMiceMice, TransgenicRatsRats, WistarChemokinestau ProteinsAlzheimer’s diseasecarbon-12chemokinesinterleukinsionizing radiationneuroinflammationspatial learning

Identifiers

PMID37833582
OpenAlexW4387621303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.