Observational studyScientific reports2023
Associations between fluid overload and outcomes in critically ill patients with acute kidney injury: a retrospective observational study.
Observational study in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Integrated haemodynamic monitoring of fluid responsiveness and fluid tolerance in critical care: from physiology to bedside applications.Journal of clinical monitoring and computing · 2026Review
- HOPFIT: A neuro-cardiovascular monitoring framework for precision sedation, anaesthesia, and resuscitation.Journal of clinical monitoring and computing · 2026Review
- AKI as a systemic syndrome and its impact on other organ systems.Critical care (London, England) · 2026Review
- Prognostic Impact of Cumulative Fluid Balance in Critically Ill Patients: A Retrospective Cohort Study.Cureus · 2026Article
- High blood pressure-targeted management associated with reduced benefits of higher body mass index in elderly patients with septic shock: a post hoc analysis of a multicenter randomized controlled trial.Annals of intensive care · 2026Article
- Personalized Fluid Management in Patients With Sepsis and Acute Kidney Injury: A Causal Machine Learning Approach.Critical care explorations · 2025Article
- Association between estimated plasma volume status and risk of sepsis-associated acute kidney Injury: a retrospective cohort study using the MIMIC-IV database.Renal failure · 2025Article
- Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025Article
- A Comprehensive Review of Fluid Resuscitation Strategies in Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Managing acute kidney injury: Evaluating amino acid infusion and conventional therapies.International urology and nephrology · 2025Article
- The Impact of Postoperative Albumin Levels on Furosemide Efficacy in Infants with Congenital Heart Disease.Life (Basel, Switzerland) · 2024Article
- 10 tips on how to use dynamic risk assessment and alerts for AKI.Clinical kidney journal · 2024Review
- Retrospective Evaluation of Risk Factors and Outcome in Dogs With and Without Fluid Overload During Hospitalization.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased fluid overload (FO) is associated with poor outcomes in critically ill patients, especially in acute kidney injury (AKI). However, the exact timing from when FO influences outcomes remains unclear. We retrospectively screened intensive care unit (ICU) admitted patients with AKI between January 2011 and December 2015. Logistic or linear regression analyses were performed to determine when hourly %FO was significant on 90-day in-hospital mortality (primary outcome) or ventilator-free days (VFDs). In total, 1120 patients were enrolled in this study. Univariate analysis showed that a higher %FO was significantly associated with higher mortality from the first hour of ICU admission (odds ratio 1.34, 95% confidence interval 1.15-1.56, P < 0.001), whereas multivariate analysis adjusted with age, sex, APACHE II score, and sepsis etiology showed the association was significant from the 27th hour. Both univariate and multivariate analyses showed that a higher %FO was significantly associated with shorter VFDs from the 1st hour. The significant associations were retained during all following observation periods after they showed significance. In patients with AKI, a higher %FO was associated with higher mortality and shorter VFDs from the early phase after ICU admission. FO should be administered with a physiological target or goal in place from the initial phase of critical illness.
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Registered trials
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