ArticleNature communications2023
The parasitic nematode Strongyloides ratti exists predominantly as populations of long-lived asexual lineages.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Population structure and punctuated genomic hyper-diversity in Caenorhabditis briggsae.Molecular biology and evolution · 2026Article
- Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.PLoS neglected tropical diseases · 2026Article
- Retrospective screening reveals the rare occurrence of zoonoticParasitology · 2026Article
- Taxonomy ofParasitology · 2026Review
- Population genomics reveals an ancient origin of heartworms in canids.Communications biology · 2026Article
- Genomes of the entomopathogenic nematode Steinernema hermaphroditum and its associated bacteria.Genetics · 2025Article
- A population genetic analysis of the nematodeProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The long and short of hyperdivergent regions.Trends in genetics : TIG · 2025Review
- The genetic diversity of Strongyloides papillosus in Pakistani goats revealed by whole genome sequencing.Parasites & vectors · 2024Article
- Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments.PLoS neglected tropical diseases · 2024Article
- Thermosensory behaviors of the free-living life stages ofbioRxiv : the preprint server for biology · 2024Article
- AdvancingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Article
- Ancient diversity in host-parasite interaction genes in a model parasitic nematode.Nature communications · 2023Article
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Authors and funding
5 authors.
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Abstract
Nematodes are important parasites of people and animals, and in natural ecosystems they are a major ecological force. Strongyloides ratti is a common parasitic nematode of wild rats and we have investigated its population genetics using single-worm, whole-genome sequencing. We find that S. ratti populations in the UK consist of mixtures of mainly asexual lineages that are widely dispersed across a host population. These parasite lineages are likely very old and may have originated in Asia from where rats originated. Genes that underly the parasitic phase of the parasite's life cycle are hyperdiverse compared with the rest of the genome, and this may allow the parasites to maximise their fitness in a diverse host population. These patterns of parasitic nematode population genetics have not been found before and may also apply to Strongyloides spp. that infect people, which will affect how we should approach their control.
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