ArticleNature communications2023
PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Regulation and roles of mammalian mitophagy.Nature reviews. Molecular cell biology · 2026Review
- Activation of AMPK as a therapeutic strategy for FBXL4-related mitochondrial DNA depletion syndrome.EMBO molecular medicine · 2026Article
- Sustained loss ofbioRxiv : the preprint server for biology · 2026Article
- Mass spectrometry proteomics for studying mitostasis.Protein science : a publication of the Protein Society · 2026Review
- Molecular diversity of mitochondrial autophagy receptors: context-dependent effects in human health and disease.Cell death discovery · 2026Review
- Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy.Research square · 2026Article
- Mitophagy in pancreatic cancer: mechanistic insights and implications for novel therapeutic strategies.Cell death discovery · 2026Review
- Upregulation of PPTC7 in brain microvascular endothelial cell aggravates diabetic cognitive dysfunction by impairing PHB2 mediated mitochondrial function.Redox biology · 2026Article
- Mechanism of autophagy initiation by transmembrane selective autophagy receptors.The EMBO journal · 2025Review
- BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammation.Autophagy · 2025Article
- Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.Nature cell biology · 2025Article
- Stressful situations: Molecular insights on mitochondrial quality control pathways.The Journal of biological chemistry · 2025Review
- Legionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins.PLoS biology · 2025Article
- NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy.Scientific reports · 2025Article
- PPTC7 acts as an essential co-factor of the SCFCell death & disease · 2025Article
- Coordinating BNIP3/NIX-mediated mitophagy in space and time.Biochemical Society transactions · 2024Review
- Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX.Life science alliance · 2024Article
- Opa1 processing is dispensable in mouse development but is protective in mitochondrial cardiomyopathy.Science advances · 2024Article
- PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFEMBO reports · 2024Article
- Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species.Cell death and differentiation · 2024Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Natalie M NiemiMorgridge Institute for Research, Madison, WI, 53715, USA. niemi@wustl.edu.ORCID http://orcid.org/0000-0002-5174-4005
Lia R SerranoDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Laura K MuehlbauerDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Catherine E BalnisDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Lianjie WeiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Andrew J SmithDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID http://orcid.org/0000-0002-4327-5886
Keri-Lyn KozulSchool of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD, 4072, Australia.
Merima FornyDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Olivia M ConnorDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Edrees H RashanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Evgenia ShishkovaDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID http://orcid.org/0000-0001-6097-6097
Kathryn L SchuelerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Mark P KellerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID http://orcid.org/0000-0002-7405-5552
Alan D AttieDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID http://orcid.org/0000-0002-0568-2261
Jonathan R FriedmanDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID http://orcid.org/0000-0001-8155-2429
Julia K PaganSchool of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD, 4072, Australia.
Joshua J CoonMorgridge Institute for Research, Madison, WI, 53715, USA.ORCID http://orcid.org/0000-0002-0004-8253
David J PagliariniMorgridge Institute for Research, Madison, WI, 53715, USA. pagliarini@wustl.edu.ORCID http://orcid.org/0000-0002-0001-0087
University of Wisconsin–Madison · USWashington University in St. Louis · USThe University of Queensland · AUThe University of Texas Southwestern Medical Center · US
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MInstitutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7MTR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1MGenetic Control of Metabolic Flux in Response to DietRC2DK125961 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ATTIE, ALAN D · 2020 to 2024
$8.1MThe Diversity Outbred Diabetes ProjectR01DK101573 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Alan D Attie · 2014 to 2026
$5.3MRegulation of Mitochondrial Metabolism by Post-Translational ModificationsR01DK098672 · NIDDK · WASHINGTON UNIVERSITY · PI David J Pagliarini · 2013 to 2026
$4.8MSpatial Organization of the Mitochondrial Inner MembraneR35GM137894 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Jonathan R. Friedman · 2020 to 2026
$3.1MThe Role of Sorcs1 and Sortilin in Diabetes SusceptibilityR01DK102948 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI ATTIE, ALAN D · 2015 to 2019
$1.7MDelineating phosphorylation-mediated regulation of mitochondrial functionR35GM151130 · NIGMS · WASHINGTON UNIVERSITY · PI Natalie Niemi · 2023 to 2026
$1.6MNCI NIH HHS P30 CA014520NHGRI NIH HHS T32 HG002760NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK098672NIDDK NIH HHS R01 DK101573NIDDK NIH HHS R01 DK102948NIDDK NIH HHS RC2 DK125961NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM137894NIGMS NIH HHS R35 GM151130
Abstract
PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant mitochondrial protein phosphorylation, suffer from a range of metabolic defects, and fail to survive beyond one day after birth. Using an inducible knockout model, we reveal that loss of Pptc7 in adult mice causes marked reduction in mitochondrial mass and metabolic capacity with elevated hepatic triglyceride accumulation. Pptc7 knockout animals exhibit increased expression of the mitophagy receptors BNIP3 and NIX, and Pptc7
Indexed as
Mitochondrial ProteinsMitophagyAnimalsFibroblastsMiceMitochondriaPhosphoric Monoester HydrolasesMitochondrial ProteinsPhosphoric Monoester Hydrolases
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