Evidence map›Paper›PMID 37833074›Full record

ArticleLife science alliance2024

Structural insights into the complex of oncogenic KRas4B

Mishal Tariq, Teppei Ikeya, Naoyuki Togashi, Louise Fairall, Shun Kamei, Sannojah Mayooramurugan, Lauren R Abbott, Anab Hasan, Carlos Bueno-Alejo, Sakura Sukegawa and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Mishal TariqDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-2737-8567
Teppei IkeyaDepartment of Chemistry, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0000-0002-6721-3727
Naoyuki TogashiDepartment of Chemistry, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0000-0003-2618-5034
Louise FairallDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0001-9456-3047
Shun KameiDepartment of Chemistry, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0000-0001-7715-7485
Sannojah MayooramuruganDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0009-0000-8300-344X
Lauren R AbbottDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0001-9466-1982
Anab HasanDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0009-0004-9681-6350
Carlos Bueno-AlejoLeicester Institute of Structure and Chemical Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-8762-6203
Sakura SukegawaDepartment of Chemistry, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0009-0002-0949-3246
Beatriz Romartinez-AlonsoDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-3061-6696
Miguel Angel Muro CampilloDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-0300-339X
Andrew J HudsonLeicester Institute of Structure and Chemical Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-1849-9666
Yutaka ItoDepartment of Chemistry, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0000-0002-1030-4660
John Wr SchwabeDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-2865-4383
Cyril DominguezDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-3575-8922
Kayoko TanakaDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK kt96@le.ac.uk.ORCID https://orcid.org/0000-0002-2905-3603
University of Leicester · GBTokyo Metropolitan University · JP

Funding

Biotechnology and Biological Sciences Research Council BB/T00746X/1Wellcome TrustWellcome Trust 204801/Z/16/Z
6 · The paper itself

Abstract

About a quarter of total human cancers carry mutations in Ras isoforms. Accumulating evidence suggests that small GTPases, RalA, and RalB, and their activators, Ral guanine nucleotide exchange factors (RalGEFs), play an essential role in oncogenic Ras-induced signalling. We studied the interaction between human KRas4B and the Ras association (RA) domain of Rgl2 (Rgl2

Indexed as

Monomeric GTP-Binding ProteinsGenes, rasHumansProtein IsoformsSignal TransductionMonomeric GTP-Binding ProteinsProtein Isoforms

Identifiers

PMID37833074
PMCPMC10576006
OpenAlexW4387611376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.