Evidence map›Paper›PMID 37832765›Full record

ArticleEnvironmental research2023

Early-life exposure to residential black carbon and childhood cardiometabolic health.

Chloe Friedman, Dana Dabelea, Deborah H Glueck, William B Allshouse, John L Adgate, Kayleigh P Keller, Sheena E Martenies, Sheryl Magzamen, Anne P Starling

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Prenatal black carbon exposure and DNA methylation in umbilical cord blood.International journal of hygiene and environmental health · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Chloe FriedmanDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: chloe.friedman@cuanschutz.edu.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Deborah H GlueckLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
William B AllshouseDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
John L AdgateDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kayleigh P KellerDepartment of Statistics, Colorado State University, Fort Collins, CO, USA.
Sheena E MarteniesDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Sheryl MagzamenDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Department of Epidemiology, Colorado School of Public Health, Colorado State University, Fort Collins, CO, USA.
Anne P StarlingDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Colorado School of Public Health · USColorado State University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Illinois Urbana-Champaign · USUniversity of North Carolina at Chapel Hill · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUH3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI Traci Allison Bekelman, Dana Dabelea · 2018 to 2026
$14.8M
Exploring the Fuel-Mediated Programming of Neonatal GrowthR01DK076648 · NIDDK · UNIVERSITY OF COLORADO DENVER/HSC DENVER · PI DABELEA, DANA · 2009 to 2018
$7.0M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUG3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI BEKELMAN, TRACI ALLISON, DABELEA, DANA · 2016 to 2024
$5.9M
A mechanistic study of prenatal air pollution exposure and offspring obesity riskR00ES025817 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI STARLING, ANNE · 2017 to 2019
$713k
Prenatal and early-life black carbon exposure and childhood cardiometabolic healthF31ES034938 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI FRIEDMAN, CHLOE S · 2023 to 2024
$57k
NCATS NIH HHS UL1 TR001082NCATS NIH HHS UL1 TR002535NCATS NIH HHS UM1 TR004399NIDDK NIH HHS R01 DK076648NIEHS NIH HHS F31 ES034938NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R00 ES025817NIH HHS UG3 OD023248NIH HHS UH3 OD023248
6 · The paper itself

Abstract

backgroundEarly life exposure to air pollution, such as particulate matter ≤2.5 μm (PM

methodsThis study included 578 mother-child pairs enrolled in the Healthy Start study (2009-2014) living in the Denver-metro area. Using a spatiotemporal prediction model, we assessed average residential black carbon levels during pregnancy and in the year prior to the early childhood follow-up visit at approximately 5 years old. We estimated associations between prenatal and early childhood BC and indicators of adiposity and cardiometabolic biomarkers in early childhood (mean 4.8 years; range, 4.0, 8.3), using linear regression.

resultsWe found higher early childhood BC was associated with higher percent fat mass, fat mass index, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR), and lower leptin and waist circumference at approximately 5 years old, after adjusting for covariates. For example, per interquartile range (IQR) increase in early childhood BC (IQR, 0.49 μg/m

conclusionsHigher early childhood, but not in utero, ambient concentrations of black carbon, a component of air pollution, were associated with greater adiposity and altered insulin homeostasis at approximately 5 years old. Future studies should examine whether these changes persist later in life.

Indexed as

Air PollutantsAir PollutionCardiovascular DiseasesCarbonChild, PreschoolEnvironmental ExposureFemaleHumansInsulinObesityParticulate MatterPregnancySootAir PollutantsCarbonInsulinParticulate MatterSootAdiposityAir pollutionBlack carbonEarly childhoodLipidsPrenatal exposure

Identifiers

PMID37832765
PMCPMC10842121
OpenAlexW4387521956

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.