ArticleProgress in neurobiology2023
Adverse and compensatory neurophysiological slowing in Parkinson's disease.
Article in Progress in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- Thalamo-cortical white matter connectivity-defined thalamic subarea volumes predict individual delay discounting.Molecular psychiatry · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- Individual cases of Parkinson's disease can be robustly classified using magnetoencephalography.NPJ Parkinson's disease · 2026Article
- Varying patterns of association between cortical large-scale networks and subthalamic nucleus activity in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Peripheral Mitochondrial Energetics are Associated with Cortical Neurophysiological Alterations in Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Normative modeling of MEG brain oscillations across the human lifespan.Communications biology · 2026Article
- Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players.iScience · 2026Article
- Divergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing.Progress in neurobiology · 2026Article
- Magnetoencephalography-based prediction of longitudinal symptom progression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.Brain communications · 2026Review
- Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease.Brain : a journal of neurology · 2025Article
- Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation.NPJ Parkinson's disease · 2025Review
- Reduced Cortical Excitability is Associated with Cognitive Symptoms in Concussed Adolescent Football Players.medRxiv : the preprint server for health sciences · 2024Article
- Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- The neurophysiological brain-fingerprint of Parkinson's disease.EBioMedicine · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with Parkinson's disease (PD) exhibit multifaceted changes in neurophysiological brain activity, hypothesized to represent a global cortical slowing effect. Using task-free magnetoencephalography and extensive clinical assessments, we found that neurophysiological slowing in PD is differentially associated with motor and non-motor symptoms along a sagittal gradient over the cortical anatomy. In superior parietal regions, neurophysiological slowing reflects an adverse effect and scales with cognitive and motor impairments, while across the inferior frontal cortex, neurophysiological slowing is compatible with a compensatory role. This adverse-to-compensatory gradient is sensitive to individual clinical profiles, such as drug regimens and laterality of symptoms; it is also aligned with the topography of neurotransmitter and transporter systems relevant to PD. We conclude that neurophysiological slowing in patients with PD signals both deleterious and protective mechanisms of the disease, from posterior to anterior regions across the cortex, respectively, with functional and clinical relevance to motor and cognitive symptoms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.