Evidence map›Paper›PMID 37832036›Full record

ArticleThe Journal of infectious diseases2023

Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection.

Maureen Carey, Tuhinur Arju, James A Cotton, Masud Alam, Mamun Kabir, Abu S G Faruque, Rashidul Haque, William A Petri, Carol A Gilchrist

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02764918 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Field Studies of Cryptosporidiosis and Enteropathogens in Bangladesh

TypeobservationalSponsorUniversity of VirginiaRan2024 to 2029Enrolled150ConditionsCryptosporidiosis
NCT07615842 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessing the Impact of Unnecessary Antibiotic Treatment on the Development of Appropriate Adaptive Immune Responses in Malnourished Bangladeshi Infants

TypeinterventionalSponsorUniversity of VirginiaRan2026 to 2028Enrolled150ConditionsAntibiotic Resistance PreventionArmsAzithromycin
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Molecular detection and zoonotic potential ofFood and waterborne parasitology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Maureen CareyDepartments of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Tuhinur ArjuInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
James A CottonWellcome Sanger Institute, Cambridge, United Kingdom.
Masud AlamInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
Mamun KabirInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
Abu S G FaruqueInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
Rashidul HaqueInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
William A PetriDepartments of Medicine, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-7268-1218
Carol A GilchristDepartments of Medicine, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0001-5027-1034
International Centre for Diarrhoeal Disease Research · BDUniversity of Virginia · USWellcome Sanger Institute · GB

Funding

FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
Nanoformulation of Synergistic TLR Ligands to Enhance Amebiasis Vaccine EfficacyR21AI109118 · NIAID · ACCESS TO ADVANCED HEALTH INSTITUTE · PI FOX, CHRISTOPHER B · 2014 to 2015
$445k
Subunit Vaccine for CryptosporidiosisR21AI154862 · NIAID · UNIVERSITY OF VIRGINIA · PI PETRI, WILLIAM A · 2021 to 2022
$444k
Cryptosporidia GenomicsR21AI142656 · NIAID · UNIVERSITY OF VIRGINIA · PI GILCHRIST, CAROL A · 2019 to 2020
$432k
NIAID NIH HHS R01 AI043596NIAID NIH HHS R21 AI109118NIAID NIH HHS R21 AI142656NIAID NIH HHS R21 AI154862Wellcome Trust
6 · The paper itself

Abstract

Cryptosporidium species are a major cause of diarrhea and associated with growth failure. There is currently only limited knowledge of the parasite's genomic variability. We report a genomic analysis of Cryptosporidium parvum isolated from Bangladeshi infants and reanalysis of sequences from the United Kingdom. Human isolates from both locations shared 154 variants not present in the cattle-derived reference genome, suggesting host-specific adaptation of the parasite. Remarkably 34.6% of single-nucleotide polymorphisms unique to human isolates were nonsynonymous and 8.2% of these were in secreted proteins. Linkage disequilibrium decay indicated frequent recombination. The genetic diversity of C. parvum has potential implications for vaccine and therapeutic design. Clinical Trials Registration. NCT02764918.

Indexed as

CryptosporidiosisCryptosporidiumCryptosporidium parvumParasitesAnimalsBangladeshCattleChildGenomicsHumansInfantCryptosporidiumgenome sequencesparasiteSNPs

Identifiers

PMID37832036
PMCPMC10629705
OpenAlexW4387633929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.