Evidence map›Paper›PMID 37831759›Full record

ArticleScience immunology2023

Integrin α3 promotes T

Eunchong Park, William E Barclay, Alejandro Barrera, Tzu-Chieh Liao, Harmony R Salzler, Timothy E Reddy, Mari L Shinohara, Maria Ciofani

Open access · greenAbstract read
In one paragraph

Article in Science immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Contextualizing TNature reviews. Immunology · 2026
    Review
  3. Article
  4. ZIP3 is essential for the encephalitogenic function of pTh17 cells by regulating intracellular zinc levels.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Th17 cell pathogenicity in autoimmune disease.Experimental & molecular medicine · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eunchong ParkDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-8018-664X
William E BarclayDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC, USA.
Alejandro BarreraCenter for Advanced Genomic Technologies, Duke University, Durham, NC, USA.ORCID 0000-0001-9244-9822
Tzu-Chieh LiaoDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-9992-8199
Harmony R SalzlerDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-1544-8700
Timothy E ReddyCenter for Advanced Genomic Technologies, Duke University, Durham, NC, USA.ORCID 0000-0002-7629-061X
Mari L ShinoharaDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-6808-9844
Maria CiofaniDepartment of Integrative Immunobiology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-6472-5260
Duke University · US

Funding

Regulatory Mechanisms of CD4+ T Cell DifferentiationUM1HG009428 · NHGRI · DUKE UNIVERSITY · PI CIOFANI, MARIA, CRAWFORD, GREGORY E · 2017 to 2021
$4.6M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
The role of AP-1 family transcription factor networks in regulating TH17 cell effector identityR01GM115474 · NIGMS · DUKE UNIVERSITY · PI CIOFANI, MARIA · 2016 to 2024
$3.2M
Deciphering the role of noncoding variation in the pathogenesis of multiple sclerosisR01AI156186 · NIAID · DUKE UNIVERSITY · PI CIOFANI, MARIA · 2021 to 2025
$3.1M
Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infectionsR01AI160737 · NIAID · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.7M
Protective role of Clec7a/dectin-1 in CNS autoimmunityR01NS120417 · NINDS · DUKE UNIVERSITY · PI SHINOHARA, MARI L. · 2021 to 2025
$2.0M
NHGRI NIH HHS UM1 HG009428NIAID NIH HHS R01 AI156186NIAID NIH HHS R01 AI160737NIAID NIH HHS T32 AI052077NIGMS NIH HHS R01 GM115474NINDS NIH HHS R01 NS120417
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) caused by CNS-infiltrating leukocytes, including T

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAnimalsCentral Nervous SystemHumansIntegrin alpha3Neuroinflammatory DiseasesIntegrin alpha3

Identifiers

PMID37831759
PMCPMC10821720
OpenAlexW4387628492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.