Evidence map›Paper›PMID 37831350›Full record

ReviewCanadian journal of anaesthesia = Journal canadien d'anesthesie2023

Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review.

Justin Lu, Keyvan Karkouti, Miki Peer, Marina Englesakis, Philip C Spinella, Torunn O Apelseth, Thomas G Scorer, Walter H A Kahr, Mark McVey, Vivek Rao and 6 more

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Platelet Storage-Problems, Improvements, and New Perspectives.International journal of molecular sciences · 2024
    Review
  5. Preservation of recipient plasma sphingosine-1-phosphate levels reduces transfusion-related acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Justin LuTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Keyvan KarkoutiDepartment of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
Miki PeerDepartment of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
Marina EnglesakisLibrary & Information Services, University Health Network, Toronto, ON, Canada.
Philip C SpinellaDepartment of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Torunn O ApelsethDepartment of Immunology and Transfusion Medicine, Haukeland University Hospital, University of Bergen, Bergen, Norway.
Thomas G ScorerCentre of Defence Pathology, Royal Centre for Defence Medicine, Birmingham, UK.
Walter H A KahrDivision of Haematology/Oncology, The Hospital for Sick Children (SickKids), Toronto, ON, Canada.
Mark McVeyDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Vivek RaoDivision of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
Lusine AbrahamyanInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Lani LiebermanDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Holly MewhortDepartment of Surgery, School of Medicine, Queen's University, Kingston, ON, Canada.
Dana V DevineCanadian Blood Services, Vancouver, BC, Canada.
Jeannie CallumQuality in Utilization, Education and Safety in Transfusion Research Program, University of Toronto, Toronto, ON, Canada.
Justyna BartoszkoDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. justyna.bartoszko@uhn.ca.ORCID http://orcid.org/0000-0002-0738-0451
University of Toronto · CAUniversity Health Network · CAHaukeland University Hospital · NOQueen's University · CARoyal Navy · GBToronto Public Health · CAUniversity of British Columbia · CAUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCold-stored platelets (CSP) are an increasingly active topic of international research. They are maintained at 1-6 °C, in contrast to standard room-temperature platelets (RTP) kept at 20-24 °C. Recent evidence suggests that CSP have superior hemostatic properties compared with RTP. This narrative review explores the application of CSP in adult cardiac surgery, summarizes the preclinical and clinical evidence for their use, and highlights recent research. SOURCE: A targeted search of MEDLINE and other databases up to 24 February 2022 was conducted. Search terms combined concepts such as cardiac surgery, blood, platelet, and cold-stored. Searches of trial registries ClinicalTrials.gov and WHO International Clinical Trials Registry Platform were included. Articles were included if they described adult surgical patients as their population of interest and an association between CSP and clinical outcomes. References of included articles were hand searched. PRINCIPAL

findingsWhen platelets are stored at 1-6 °C, their metabolic rate is slowed, preserving hemostatic function for increased storage duration. Cold-stored platelets have superior adhesion characteristics under physiologic shear conditions, and similar or superior aggregation responses to physiologic agonists. Cold-stored platelets undergo structural, metabolic, and molecular changes which appear to "prime" them for hemostatic activity. While preliminary, clinical evidence supports the conduct of trials comparing CSP with RTP for patients with platelet-related bleeding, such as those undergoing cardiac surgery.

conclusionCold-stored platelets may have several advantages over RTP, including increased hemostatic capacity, extended shelf-life, and reduced risk of bacterial contamination. Large clinical trials are needed to establish their potential role in the treatment of acutely bleeding patients.

Indexed as

Cardiac Surgical ProceduresHemostaticsAdultBlood PlateletsBlood PreservationCold TemperatureHemorrhageHumansHemostaticscold-preservedhemostasisplatelet additive solutionsplateletsstorage lesions

Identifiers

PMID37831350
OpenAlexW4387598198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.