Evidence map›Paper›PMID 37831280›Full record

ArticleAnnals of surgical oncology2024

Is Systemic Chemotherapy Useful in Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases? A Propensity-Score Analysis.

Marco Tonello, Dario Baratti, Paolo Sammartino, Andrea Di Giorgio, Manuela Robella, Cinzia Sassaroli, Massimo Framarini, Mario Valle, Antonio Macrì, Luigina Graziosi and 19 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 15 institutions in 1 country.

Marco TonelloUnit of Surgical Oncology of Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Dario BarattiPeritoneal Surface Malignancy Unit, Dept. of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Paolo SammartinoCytoreductive Surgery and HIPEC Unit, Department of Surgery "Pietro Valdoni", Sapienza University of Rome, Rome, Italy.
Andrea Di GiorgioSurgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Manuela RobellaSurgical Oncology Unit, Candiolo Cancer Institute, Candiolo, Turin, Italy.
Cinzia SassaroliAbdominal Oncology Department, Fondazione Giovanni Pascale, IRCCS, Naples, Italy.
Massimo FramariniGeneral and Oncologic Department of Surgery, Morgagni - Pierantoni Hospital, AUSL Romagna, Forlì, Italy.
Mario VallePeritoneal Tumours Unit, IRCCS, Regina Elena Cancer Institute, Rome, Italy.
Antonio MacrìDepartment of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, Messina, Italy.
Luigina GraziosiGeneral and Emergency Surgery Department, University of Perugia, Santa Maria Della Misericordia Hospital, Perugia, Italy.
Federico CoccoliniGeneral Emergency and Trauma Surgery, Bufalini Hospital, Cesena, Italy.
Piero Vincenzo LippolisGeneral and Peritoneal Surgery, Department of Surgery, Hospital University Pisa (AOUP), Pisa, Italy.
Roberta GelminiGeneral and Oncological Surgery Unit, AOU of Modena University of Modena and Reggio Emilia, Modena, Italy.
Marcello DeracoPeritoneal Surface Malignancy Unit, Dept. of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Daniele BiacchiCytoreductive Surgery and HIPEC Unit, Department of Surgery "Pietro Valdoni", Sapienza University of Rome, Rome, Italy.
Francesco SantulloSurgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Marco VairaSurgical Oncology Unit, Candiolo Cancer Institute, Candiolo, Turin, Italy.
Katia Di LauroDepartment of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
Fabrizio D'AcapitoGeneral and Oncologic Department of Surgery, Morgagni - Pierantoni Hospital, AUSL Romagna, Forlì, Italy.
Fabio CarboniPeritoneal Tumours Unit, IRCCS, Regina Elena Cancer Institute, Rome, Italy.
Erica MiloneUniversity Hospital "G. Martino", Messina, Italy.
Annibale DoniniGeneral and Emergency Surgery Department, University of Perugia, Santa Maria Della Misericordia Hospital, Perugia, Italy.
Paola FugazzolaGeneral surgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Pinuccia FavianaPathological Anatomy III, Laboratory Medicine Department, Hospital University Pisa (AOUP), Pisa, Italy.
Lorena SorrentinoGeneral and Oncological Surgery Unit, AOU of Modena University of Modena and Reggio Emilia, Modena, Italy.
Elisa PizzolatoUnit of Surgical Oncology of Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Carola CenziUnit of Surgical Oncology of Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Paola Del BiancoClinical Research Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Antonio SommarivaUnit of Surgical Oncology of Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy. antonio.sommariva@iov.veneto.it.
Istituti di Ricovero e Cura a Carattere Scientifico · ITAzienda Ospedaliera Universitaria Pisana · ITCandiolo Cancer Institute · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITOspedale G.B. Morgagni - L.Pierantoni · ITSapienza University of Rome · ITUniversity of Modena and Reggio Emilia · ITUniversity of Perugia · ITAgostino Gemelli University Polyclinic · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITFederico II University Hospital · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITIstituto Oncologico Veneto · ITPoliclinico San Matteo Fondazione · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMultimodal treatment of colorectal (CRC) peritoneal metastases (PM) includes systemic chemotherapy (SC) and surgical cytoreduction (CRS), eventually with hyperthermic intraperitoneal chemotherapy (HIPEC), in select patients. Considering lack of clear guidelines, this study was designed to analyze the role of chemotherapy and its timing in patients treated with CRS-HIPEC.

methodsData from 13 Italian centers with PM expertise were collected by a collaborative group of the Italian Society of Surgical Oncology (SICO). Clinicopathological variables, SC use, and timing of administration were correlated with overall survival (OS), disease-free survival (DFS), and local (peritoneal) DFS (LDFS) after propensity-score (PS) weighting to reduce confounding factors.

resultsA total of 367 patients treated with CRS-HIPEC were included in the propensity-score weighting. Of the total patients, 19.9% did not receive chemotherapy within 6 months of surgery, 32.4% received chemotherapy before surgery (pregroup), 28.9% after (post), and 18.8% received both pre- and post-CRS-HIPEC treatment (peri). SC was preferentially administered to younger (p = 0.02) and node-positive (p = 0.010) patients. Preoperative SC is associated with increased rate of major complications (26.9 vs. 11.3%, p = 0.0009). After PS weighting, there were no differences in OS, DFS, or LDFS (p = 0.56, 0.50, and 0.17) between chemotherapy-treated and untreated patients. Considering SC timing, the post CRS-HIPEC group had a longer DFS and LDFS than the pre-group (median DFS 15.4 vs. 9.8 m, p = 0.003; median LDFS 26.3 vs. 15.8 m, p = 0.026).

conclusionsIn patients with CRC-PM treated with CRS-HIPEC, systemic chemotherapy was not associated with overall survival benefit. The adjuvant schedule was related to prolonged disease-free intervals. Additional, randomized studies are required to clarify the role and timing of systemic chemotherapy in this patient subset.

Indexed as

Colorectal NeoplasmsHyperthermia, InducedPeritoneal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyCytoreduction Surgical ProceduresHumansHyperthermic Intraperitoneal ChemotherapyRetrospective StudiesSurvival Rate

Identifiers

PMID37831280
OpenAlexW4387597798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.