Evidence map›Paper›PMID 37831156›Full record

ArticleWorld journal of urology2023

Pulsed Thulium:YAG laser - What is the lithotripsy ablation efficiency for stone dust from human urinary stones? Results from an in vitro PEARLS study.

Jia-Lun Kwok, Eugenio Ventimiglia, Vincent De Coninck, Frédéric Panthier, Yazeed Barghouthy, Alexandre Danilovic, Anil Shrestha, Niamh Smyth, Florian Alexander Schmid, Manuela Hunziker and 5 more

Open access · hybridAbstract read
In one paragraph

Article in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 9 countries.

Jia-Lun KwokDepartment of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9758-6225
Eugenio VentimigliaProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.ORCID http://orcid.org/0000-0003-3654-1629
Vincent De ConinckProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.ORCID http://orcid.org/0000-0002-4983-5055
Frédéric PanthierProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.ORCID http://orcid.org/0000-0003-3055-2984
Yazeed BarghouthyProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.ORCID http://orcid.org/0000-0001-6755-0611
Alexandre DanilovicProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.ORCID http://orcid.org/0000-0002-6963-6117
Anil ShresthaProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.ORCID http://orcid.org/0000-0002-2249-5345
Niamh SmythProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.
Florian Alexander SchmidDepartment of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-0862-5027
Manuela HunzikerDepartment of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.
Cédric PoyetDepartment of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-3648-6941
Michel DaudonHôpital Tenon, CRISTAL Laboratory, Sorbonne Université, Paris, France.
Olivier TraxerProgressive Endourological Association for Research and Leading Solutions (PEARLS), Paris, France.ORCID http://orcid.org/0000-0002-2459-3803
Daniel EberliDepartment of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8866-8010
Etienne Xavier KellerDepartment of Urology, University Hospital Zurich, University of Zurich, Frauenklinikstrasse 10, 8091, Zurich, Switzerland. etiennexavier.keller@usz.ch.ORCID http://orcid.org/0000-0003-1667-7609
University of Zurich · CHEuropean Association of Urology · NLSorbonne Université · FRBir Hospital · NPCentre Hospitalier de Valenciennes · FRHospital Alemão Oswaldo Cruz · BRMonklands Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe novel pulsed thulium:yttrium-aluminum-garnet (p-Tm:YAG) laser was recently introduced. Current studies present promising p-Tm:YAG ablation efficiency, although all are based on non-human stone models or with unknown stone composition. The present study aimed to evaluate p-Tm:YAG ablation efficiency for stone dust from human urinary stones of known compositions.

methodsCalcium oxalate monohydrate (COM) and uric acid (UA) stones were subjected to lithotripsy in vitro using a p-Tm:YAG laser generator (Thulio®, Dornier MedTech GmbH, Germany). 200 J was applied at 0.1 J × 100 Hz, 0.4 J × 25 Hz or 2.0 J × 5 Hz (average 10W). Ablated stone dust mass was calculated from weight difference between pre-lithotripsy stone and post-lithotripsy fragments > 250 µm. Estimated ablated volume was calculated using prior known stone densities (COM: 2.04 mg/mm

resultsMean ablation mass efficiency was 0.04, 0.06, 0.07 mg/J (COM) and 0.04, 0.05, 0.06 mg/J (UA) for each laser setting, respectively. This translated to 0.021, 0.029, 0.034 mm

conclusionTo our knowledge, this is the first study showing ablation efficiency of the p-Tm:YAG laser for stone dust from human urinary stones of known compositions. The p-Tm:YAG seems to ablate COM and UA equally well, with no statistically significant differences between differing laser settings.

Indexed as

Lasers, Solid-StateLithotripsyLithotripsy, LaserNephrolithiasisUrinary CalculiCalcium OxalateHolmiumHumansThuliumCalcium OxalateHolmiumThuliumAblationDustEndourologyKidney stonesLaserPulsed Thulium:YAGUreteroscopy

Identifiers

PMID37831156
PMCPMC10693514
OpenAlexW4387598767

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.