SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2023
There is no difference in the efficacy of anterior cruciate ligament reconstruction using autograft combined with or without ligament augmentation: a systematic review and meta-analysis.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Medium-term functional outcomes comparing soft-tissue autografts with allografts in primary anterior cruciate ligament reconstruction : a systematic review and meta-analysis.Bone & joint open · 2026Pooled it
- Hamstring tendon graft with LARS augmentation showed superior short-term clinical efficacy compared to hamstring tendon alone as graft in ACL reconstruction: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Clinical Retrospective Study on Superior Capsular Reconstruction Using Autologous Fascia Lata Combined With LARS Ligament for Massive Irreparable Rotator Cuff Tears.Orthopaedic surgery · 2026Article
- A clinical practice review: augmentation of meniscoligamentous structures for primary prevention of knee joint deterioration.Annals of joint · 2026Review
- LARS-augmented hamstring ACL reconstruction shows better early but similar long-term outcomes compared with hamstring autograft alone: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2026Review
- Effectiveness of synthetic vs. autologous ligaments in anterior cruciate ligament reconstruction with remnant preservation: a retrospective cohort study.Frontiers in sports and active living · 2026Article
- The in vitro elution characteristics of vancomycin from the ligament augmentation and reconstruction system.Journal of experimental orthopaedics · 2024Article
- Enhancing research methods: The role of systematic and scoping reviews in orthopaedics, sports medicine and rehabilitation.Journal of experimental orthopaedics · 2024Article
- A slight degree of osteoarthritis appears to be present after anterior cruciate ligament reconstruction compared with contralateral healthy knees at a minimum of 20 years: A systematic review of the literature.Journal of experimental orthopaedics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis study aims to determine the efficacy of anterior cruciate ligament reconstruction (ACLR) using autograft combined with or without ligament augmentation.
methodsA computerized search of the databases was conducted, including PubMed, Web of Science, Embase, Scopus and the Cochrane Library. Only prospective or retrospective comparative studies with a minimum 2-year follow-up were considered for inclusion. Two independent reviewers performed data extraction and methodological quality assessment. A Mantel-Haenszel analysis was used for the pooling of results. Sensitivity analysis was performed to maintain the stability of results. The egger test was applied to assess the publication bias.
resultsFourteen studies were included. The total cohort was 1353 patients (non-augmented group: 763 patients; augmented group: 590 patients). There were three Randomized Controlled Trials (RCTs, Level I), six retrospective comparative studies (Level III) and five case-control studies (Level III). The follow-up rate was ≥ 88% and the follow-up periods were ≥ 24 months in all included studies. The augmented graft used to compare with autograft included the Ligament Augmentation Device (LAD), the Ligament Advanced Reinforcement System (LARS) artificial ligament, FiberTape, hamstring tendon allograft, degradable poly (urethane urea). No significant differences were observed between the augmented and non-augmented groups regarding postoperative patient-reported outcomes (PROs), including the International Knee Documentation Committee score, Lysholm score and Tegner score, knee laxity, including KT-1000, side-to-side difference, Lachman test and pivot shift and rate of graft failure.
conclusionsACLR using autografts combined with ligament augmentation shows no advantages in PROs, knee laxity and graft failure rate compared with using autografts only. LEVEL OF EVIDENCE: Level III.
trial registrationThe research protocol was registered at the PROSPERO database (CRD42022324784).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.