Evidence map›Paper›PMID 37831035›Full record

Trial reportJACC. Clinical electrophysiology2023

Phase 2 Re-Entry Without I

Zhaoyang Zhang, Pedro Brugada, James N Weiss, Zhilin Qu

Open access · greenAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JACC. Clinical electrophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Zhaoyang ZhangDepartment of Physics, School of Physical Science and Technology, Ningbo University, Ningbo, Zhejiang, China; Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Pedro BrugadaHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium.
James N WeissDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Zhilin QuDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. Electronic address: zqu@mednet.ucla.edu.
University of California, Los Angeles · USNingbo University · CNVrije Universiteit Brussel · BE

Funding

Neural Control of Myocardial Excitability at the Nerve Myocyte InterfaceP01HL164311 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALYANAM SHIVKUMAR · 2023 to 2026
$11.3M
Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
Ferroptosis in the Heart: Iron Calcium Crosstalk and CompartmentalizationR01HL157116 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI GWATHMEY, JUDITH K, XIE, LAI-HUA · 2022 to 2025
$2.4M
A population-based in silico platform for arrhythmia predictionR01HL134709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN · 2018 to 2021
$1.6M
NHLBI NIH HHS P01 HL164311NHLBI NIH HHS R01 HL133294NHLBI NIH HHS R01 HL134709NHLBI NIH HHS R01 HL157116
6 · The paper itself

Abstract

backgroundIn Brugada syndrome (BrS), phase 2 re-excitation/re-entry (P2R) induced by the transient outward potassium current (I

objectivesThe authors used computer simulations to investigate how sodium channel dysfunction affects P2R-mediated arrhythmogenesis in the presence and absence of I

methodsComputer simulations were carried out in 1-dimensional cables and 2-dimensional tissue using guinea pig and human ventricular action potential models.

resultsIn the presence of I

conclusionsAltered I

Indexed as

Brugada SyndromeAction PotentialsAnimalsArrhythmias, CardiacGuinea PigsHumansPotassiumSodium ChannelsPotassiumSodium ChannelsBrugada syndromephase 2 re-entrysodium channel blockersodium channel mutation

Identifiers

PMID37831035
PMCPMC11348283
OpenAlexW4387526300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.