Evidence map›Paper›PMID 37830556›Full record

ArticleCells2023

Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity.

Elodie Ehret, Sévan Stroh, Muriel Auberson, Frédérique Ino, Yannick Jäger, Marc Maillard, Roman Szabo, Thomas H Bugge, Simona Frateschi, Edith Hummler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Epithelial Na+ Channels, Immune Cells, and Salt.Annual review of physiology · 2025
    Review
  2. Review
  3. Influence of proteolytic cleavage of ENaC's γ subunit upon NaAmerican journal of physiology. Renal physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Elodie EhretDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0003-0181-4893
Sévan StrohDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
Muriel AubersonDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0009-0007-4308-8750
Frédérique InoDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
Yannick JägerDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
Marc MaillardService of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), 1005 Lausanne, Switzerland.
Roman SzaboNational Institutes of Health/NIDCR, Bethesda, MD 20892, USA.
Thomas H BuggeNational Institutes of Health/NIDCR, Bethesda, MD 20892, USA.
Simona FrateschiDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
Edith HummlerDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-3887-2715
University of Lausanne · CHNational Institutes of Health · USMax Planck Institute for Heart and Lung Research · DEUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC in vivo. The present study tested whether CAP3/St14 is relevant for renal proteolytic ENaC activation and affects ENaC-mediated Na

Indexed as

Epithelial Sodium ChannelsSerine ProteasesAnimalsKidneyMembrane ProteinsMiceProstasinSerine EndopeptidasesEpithelial Sodium ChannelsMembrane ProteinsProstasinSerine EndopeptidasesSerine ProteasesSt14 protein, mouseCAP1/Prss8CAP3/St14proteolytic ENaC activationsodium and potassium balance

Identifiers

PMID37830556
PMCPMC10572026
OpenAlexW4386996260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.