ArticleAnnals of dermatology2023
Periorbital Skin Rejuvenation of Asian Skin Using Microneedle Fractional Radiofrequency.
Article in Annals of dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Radiofrequency Microneedling in the Treatment of Dermatological Conditions: A Systematic Review.Aesthetic plastic surgery · 2026Pooled it
- Microneedling With RF-Assisted Skin Penetration Improves the Hard-to-Treat Periorbital Wrinkles: Nonrandomized Clinical Trial.Journal of cosmetic dermatology · 2024Trial
- Dual-depth 25-pin insulated microneedle radiofrequency for moderate-to-severe periorbital wrinkles.Lasers in medical science · 2026Observational
- Sequential Monopolar-Bipolar Pulsed Radiofrequency for Non-Invasive Periorbital Rejuvenation: A Case Series.Clinical, cosmetic and investigational dermatology · 2026Article
- The Landscape of Radiofrequency Technology for Skin Rejuvenation.Health science reports · 2026Article
- Efficacy and Safety of Microneedle Fractional Radiofrequency Combined with Botulinum Toxin Type A for Periorbital Aging: A Retrospective Cohort Study.Clinical, cosmetic and investigational dermatology · 2026Article
- A Scoping Review of Radiofrequency Microneedling: Clinical Application and Outcome Assessment.Aesthetic plastic surgery · 2025Article
- Histological and clinical dose-response analysis of radiofrequency microneedling treatment for skin rejuvenation.Lasers in medical science · 2025Article
- A Prospective Study on the Efficacy and Safety of the Bipolar Radiofrequency with Multi-Channel and Vacuum-Assisted for Rejuvenation in Periorbital Area.Clinical, cosmetic and investigational dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe periorbital area plays an important role cosmetically. Periorbital wrinkles are attributed to long-term, repeated use of orbicularis oris muscles and UV-induced dermal collagen degeneration. Fractional microneedle radiofrequency (RF) treats scars and laxity by creating vertical channels of injury in the dermis, triggering a scarless healing cascade and neocollagenesis.
objectiveTo evaluate the effect and safety of a novel fractional microneedle RF device on periorbital wrinkles based on several objective indicators.
methodsEleven healthy Korean patients aged 30 to 75 years with periorbital wrinkles were included in this study. Wrinkle grades were evaluated using the Fitzpatrick wrinkle assessment scale (WAS). The melanin and erythema index, transepidermal water loss (TEWL), and three parameters for elasticity were recorded. Skin biopsies were obtained in patients who consented.
resultsAll patients exhibited wrinkle improvement in the lateral periorbital area, and two patients also showed efficacy in the lower eyelid area. There was a statistically significant decrease in WAS and a significant improvement in the melanin index of V4 and V5. TEWL also showed a considerable decline on V4 and V5, suggesting that the water content of the skin increased with repeated laser sessions. A peak increase in viscoelasticity and a decrease in retraction time following the first laser application were observed. In the histopathologic examination, the dermis had a denser collagen and elastin content.
conclusionMicroneedle fractional RF resulted in statistically significant long-term clinical improvement of periorbital wrinkles and enhanced pigmentation and skin hydration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.