Evidence map›Paper›PMID 37830367›Full record

ArticleJournal of the American Heart Association2023

Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV.

Matthew S Durstenfeld, Michael J Peluso, Matthew A Spinelli, Danny Li, Rebecca Hoh, Ahmed Chenna, Brandon Yee, John Winslow, Christos Petropoulos, Monica Gandhi and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Matthew S DurstenfeldDepartment of Medicine University of California San Francisco CA.ORCID 0000-0002-7612-3352
Michael J PelusoDepartment of Medicine University of California San Francisco CA.ORCID 0000-0003-0585-6230
Matthew A SpinelliDepartment of Medicine University of California San Francisco CA.ORCID 0000-0001-6368-8664
Danny LiDivision of Cardiology Zuckerberg San Francisco General San Francisco CA.
Rebecca HohDivision of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital University of California San Francisco CA.ORCID 0000-0001-5112-4220
Ahmed ChennaMonogram Biosciences, LabCorp South San Francisco CA.ORCID 0000-0001-6201-2494
Brandon YeeMonogram Biosciences, LabCorp South San Francisco CA.
John WinslowMonogram Biosciences, LabCorp South San Francisco CA.
Christos PetropoulosMonogram Biosciences, LabCorp South San Francisco CA.ORCID 0000-0001-5496-8090
Monica GandhiDepartment of Medicine University of California San Francisco CA.ORCID 0000-0002-7025-1994
Timothy J HenrichDepartment of Experimental Medicine University of California San Francisco CA.ORCID 0000-0002-6684-0622
Mandar A ArasDepartment of Medicine University of California San Francisco CA.
Carlin S LongDepartment of Medicine University of California San Francisco CA.ORCID 0000-0001-7251-2847
Steven G DeeksDepartment of Medicine University of California San Francisco CA.ORCID 0000-0001-6371-747X
Priscilla Y HsueDepartment of Medicine University of California San Francisco CA.ORCID 0000-0002-3427-6043
San Francisco General Hospital · USLabCorp (United States) · USUniversity of California, San Francisco · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinicR01AI158013 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA, SPINELLI, MATTHEW A. · 2020 to 2023
$3.1M
Role of Hematopoietic System and Proteomics in HIV-Associated CardiovascularDiseaseK24AI112393 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y. · 2014 to 2024
$1.9M
UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
Characterizing the virologic and immunologic signatures of HIV exceptional controlK23AI157875 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PELUSO, MICHAEL JOSEPH · 2021 to 2025
$927k
Evaluation of the Impact of HIV Status on the Immune Response to mRNA COVID-19 VaccinesR21AI167648 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA, SPINELLI, MATTHEW A. · 2022 to 2023
$444k
NCATS NIH HHS UL1 TR001872NHLBI NIH HHS K12 HL143961NHLBI NIH HHS L30 HL159695NIAID NIH HHS K23 AI157875NIAID NIH HHS K24 AI112393NIAID NIH HHS L30 AI147159NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI158013NIAID NIH HHS R21 AI167648
6 · The paper itself

Abstract

Background Postacute sequelae of COVID-19 (PASC) and HIV are both associated with reduced exercise capacity, but whether SARS-CoV-2 or PASC are associated with exercise capacity among people with HIV (PWH) is unknown. We hypothesized that PWH with PASC would have reduced exercise capacity from chronotropic incompetence. Methods and Results We conducted cross-sectional cardiopulmonary exercise testing within a COVID recovery cohort that included PWH with and without prior SARS-CoV-2 infection and people without HIV with prior SARS-CoV-2 infection (controls). We evaluated associations of HIV, SARS-CoV-2, and PASC with exercise capacity (peak oxygen consumption) and chronotropy (adjusted heart rate reserve). We included 83 participants (median age, 54 years; 35% women; 37 PWH): 23 out of 37 (62%) PWH and all 46 controls had prior SARS-CoV-2 infection, and 11 out of 23 (48%) PWH and 28 out of 46 (61%) without HIV had PASC. Peak oxygen consumption was reduced among PWH versus controls (80% predicted versus 99%,

Indexed as

COVID-19HIV InfectionsCross-Sectional StudiesExercise ToleranceFemaleHumansMaleMiddle AgedPost-Acute COVID-19 SyndromeSARS-CoV-2cardiopulmonary exercise testingcardiorespiratory fitnesschronotropic incompetenceexerciseHIVlong COVIDpostacute sequelae of SARS‐CoV‐2

Identifiers

PMID37830367
PMCPMC10757521
OpenAlexW4387597497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.