Evidence map›Paper›PMID 37830013›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)

A randomized, double-blind, placebo-controlled, parallel-group 12-week pilot phase II trial of SaiLuoTong (SLT) for cognitive function in older adults with mild cognitive impairment.

Genevieve Z Steiner-Lim, Alan Bensoussan, Elana R Andrews-Marney, Mahmoud A Al-Dabbas, Adele E Cave, Christine L Chiu, Katerina Christofides, Frances M De Blasio, Lauren S Dewsbury, Naomi L Fagan and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Subcutaneous application ofFrontiers in public health · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 3 countries.

Genevieve Z Steiner-LimNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.ORCID https://orcid.org/0000-0002-8708-6104
Alan BensoussanNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Elana R Andrews-MarneyNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Mahmoud A Al-DabbasNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Adele E CaveNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Christine L ChiuMacquarie Medical School Macquarie University Macquarie Park New South Wales Australia.
Katerina ChristofidesNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Frances M De BlasioNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Lauren S DewsburyNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Naomi L FaganNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Jack S FogartyScience of Learning in Education Centre National Institute of Education Nanyang Technological University Singapore.
Lena C HattomNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Mark I HohenbergSchool of Medicine Western Sydney University Penrith New South Wales Australia.
Deyyan JafarNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Diana KaramacoskaNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.ORCID https://orcid.org/0000-0002-8749-348X
Chai K LimMacquarie Medical School Macquarie University Macquarie Park New South Wales Australia.
Jianxun LiuXiyuan Hospital China Academy of Chinese Medical Sciences Beijing PR China.
Najwa-Joelle MetriNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
D Vincent OxenhamNeuropsychology Department Royal North Shore Hospital St. Leonards New South Wales Australia.
Holly RatajecNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Nikita RoyNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Danielle G ShiptonNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
David VarjabedianNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Dennis H ChangNICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Western Sydney University · AUMacquarie University · AUTranslational Research Institute · AUChinese Academy of Medical Sciences & Peking Union Medical College · CNNanyang Technological University · SGRoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study primarily aimed to evaluate the efficacy and safety of SaiLuoTong (SLT) on cognition in mild cognitive impairment (MCI).

methodsCommunity-dwelling people with MCI aged ≥60 years were randomly assigned to 180 mg/day SLT or placebo for 12 weeks.

resultsThirty-nine participants were randomized to each group ( DISCUSSION: SLT is well tolerated and may be useful in supporting aspects of memory retrieval and executive function in people with MCI. Highlights: SaiLuoTong (SLT) improves delayed memory retrieval and executive function in people with mild cognitive impairment (MCI).SLT is well tolerated in people ≥ 60 years.The sample of community dwellers with MCI was well characterized and homogeneous.

Indexed as

Alzheimer's diseaseclinical trialcognitive functionmild cognitive impairmentSaiLuoTong

Identifiers

PMID37830013
PMCPMC10565903
OpenAlexW4387574306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.