Evidence map›Paper›PMID 37829571›Full record

ArticleArchives of microbiology & immunology2023

A Novel Peptide that Disrupts the Lck-IP

Michael W Harr, Andrew Lavik, Karen McColl, Fei Zhong, Ben Haberer, Khadijah Aldabbagh, Vivien Yee, Clark W Distelhorst

Open access · diamondAbstract read
In one paragraph

Article in Archives of microbiology & immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michael W HarrCase Western Reserve University.
Andrew LavikCase Western Reserve University.
Karen McCollCase Western Reserve University.
Fei ZhongCase Western Reserve University.
Ben HabererCase Western Reserve University.
Khadijah AldabbaghCase Western Reserve University.
Vivien YeeCase Western Reserve University.
Clark W DistelhorstCase Western Reserve University.
Case Western Reserve University · US

Funding

RESEARCH ONCOLOGY TRAINING GRANTT32CA059366 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JACKSON, MARK W. · 1993 to 2025
$5.5M
MECHANISM OF STEROID ACTION IN LYMPHOID MALIGNANCYR01CA042755 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI DISTELHORST, CLARK W · 1985 to 2010
$3.4M
NCI NIH HHS R01 CA042755NCI NIH HHS T32 CA059366
6 · The paper itself

Abstract

There is increasing evidence that the T-cell protein, Lck, is involved in the pathogenesis of chronic lymphocytic leukemia (CLL) as well as other leukemias and lymphomas. We previously discovered that Lck binds to domain 5 of inositol 1,4,5-trisphosphate receptors (IP

Indexed as

Biochemistry, ProteinsBiological sciencesCell biologyCell deathDiseases, Hematological diseasesDrug discoveryHealth sciencesHematological cancerLeukaemia, Biological sciencesOncogene proteinsTarget identification

Identifiers

PMID37829571
PMCPMC10569261
OpenAlexW4386403414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.