ArticleAdvanced functional materials2018
Tissue-Engineered Peripheral Nerve Interfaces.
Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics.Frontiers in bioengineering and biotechnology · 2021Pooled it
- Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces.Bioelectronic medicine · 2026Review
- Don't judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good.npj biomedical innovations · 2026Review
- Soft Bioelectronic Interfaces for Continuous Peripheral Neural Signal Recording and Robust Cross-Subject Decoding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Biodegradable Medical Implants: Reshaping Future Medical Practice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Controlled Magnesium Ion Delivery via Mg-Sputtered Nerve Conduit for Enhancing Peripheral Nerve Regeneration.Advanced healthcare materials · 2025Article
- A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries.Nature communications · 2025Article
- Hyaluronic Acid-Based 3D Bioprinted Hydrogel Structure for Directed Axonal Guidance and Modeling Innervation In Vitro.Advanced healthcare materials · 2025Article
- Enhancing facial nerve regeneration with scaffold-free conduits engineered using dental pulp stem cells and their endogenous, aligned extracellular matrix.Journal of neural engineering · 2024Article
- Design, Fabrication, and Implantation of Hollow Tissue-Engineered Electronic Nerve Interfaces.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Impact of the Reduction Time-Dependent Electrical Conductivity of Graphene Nanoplatelet-Coated AlignedACS applied bio materials · 2024Article
- Nerve Reconstruction Using ActiGraft Blood Clot in Rabbit Acute Peripheral Injury Model: Preliminary Study.Bioengineering (Basel, Switzerland) · 2024Article
- Skin derived precursors induced Schwann cells mediated tissue engineering-aided neuroregeneration across sciatic nerve defect.Bioactive materials · 2024Article
- Key challenges in exploring the rat as a preclinical neurostimulation model for aortic baroreflex modulation in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair.Frontiers in cell and developmental biology · 2024Review
- Electrospun Nanofibrous Conduit Filled with a Collagen-Based Matrix (ColM) for Nerve Regeneration.Molecules (Basel, Switzerland) · 2023Article
- Neuro-regenerative behavior of adipose-derived stem cells in aligned collagen I hydrogels.Materials today. Bio · 2023Article
- Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Microtubes with gradient decellularized porcine sciatic nerve matrix from microfluidics for sciatic nerve regeneration.Bioactive materials · 2023Article
- Carbohydrate based biomaterials for neural interface applications.Journal of materials chemistry. B · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Research on neural interfaces has historically concentrated on development of systems for the brain; however, there is increasing interest in peripheral nerve interfaces (PNIs) that could provide benefit when peripheral nerve function is compromised, such as for amputees. Efforts focus on designing scalable and high-performance sensory and motor peripheral nervous system interfaces. Current PNIs face several design challenges such as undersampling of signals from the thousands of axons, nerve-fiber selectivity, and device-tissue integration. To improve PNIs, several researchers have turned to tissue engineering. Peripheral nerve tissue engineering has focused on designing regeneration scaffolds that mimic normal nerve extracellular matrix composition, provide advanced microarchitecture to stimulate cell migration, and have mechanical properties like the native nerve. By combining PNIs with tissue engineering, the goal is to promote natural axon regeneration into the devices to facilitate close contact with electrodes; in contrast, traditional PNIs rely on insertion or placement of electrodes into or around existing nerves, or do not utilize materials to actively facilitate axon regeneration. This review presents the state-of-the-art of PNIs and nerve tissue engineering, highlights recent approaches to combine neural-interface technology and tissue engineering, and addresses the remaining challenges with foreign-body response.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.