Evidence map›Paper›PMID 37829345›Full record

ArticleFrontiers in oncology2023

Ayman Abouzayed, Kamila Seitova, Fanny Lundmark, Vitalina Bodenko, Maryam Oroujeni, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Preclinical Evaluation of a Novel High-Affinity Radioligand [International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ayman AbouzayedDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Kamila SeitovaScientific and Research Laboratory of Chemical and Pharmaceutical Research, Siberian State Medical University, Tomsk, Russia.
Fanny LundmarkDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Vitalina BodenkoScientific and Research Laboratory of Chemical and Pharmaceutical Research, Siberian State Medical University, Tomsk, Russia.
Maryam OroujeniDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Vladimir TolmachevResearch Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk, Russia.
Ulrika RosenströmDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Uppsala University · SETomsk Polytechnic University · RUScience for Life Laboratory · SESiberian State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Prostate specific membrane antigen (PSMA), highly expressed in metastatic castration-resistant prostate cancer (mCRPC), is an established therapeutic target. Theranostic PSMA-targeting agents are widely used in patient management and has shown improved outcomes for mCRPC patients. Earlier, we optimized a urea-based probe for radionuclide visualization of PSMA-expression Methods: BQ7876 was synthesized and labeled with Lu-177. Specificity and affinity of [ Results: BQ7876 was labeled with Lu-177 with radiochemical yield >99%. Its binding to PSMA was specific Discussion: Biodistribution studies in mice demonstrated that targeting properties of [

Indexed as

dosimetrylutetium-177PC3-pip cellsprostate cancerPSMA

Identifiers

PMID37829345
PMCPMC10565663
OpenAlexW4387137719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.