Evidence map›Paper›PMID 37829176›Full record

ArticleNAR genomics and bioinformatics2023

Superior protein thermophilicity prediction with protein language model embeddings.

Florian Haselbeck, Maura John, Yuqi Zhang, Jonathan Pirnay, Juan Pablo Fuenzalida-Werner, Rubén D Costa, Dominik G Grimm

Abstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Florian HaselbeckTechnical University of Munich, Campus Straubing for Biotechnology and Sustainability, Bioinformatics, 94315 Straubing, Germany.ORCID https://orcid.org/0000-0002-5702-376X
Maura JohnTechnical University of Munich, Campus Straubing for Biotechnology and Sustainability, Bioinformatics, 94315 Straubing, Germany.
Yuqi ZhangTechnical University of Munich, Campus Straubing for Biotechnology and Sustainability, Bioinformatics, 94315 Straubing, Germany.
Jonathan PirnayTechnical University of Munich, Campus Straubing for Biotechnology and Sustainability, Bioinformatics, 94315 Straubing, Germany.
Juan Pablo Fuenzalida-WernerTechnical University of Munich, Campus Straubing for Biotechnology and Sustainability, Chair of Biogenic Functional Materials, 94315 Straubing, Germany.
Rubén D CostaTechnical University of Munich, Campus Straubing for Biotechnology and Sustainability, Chair of Biogenic Functional Materials, 94315 Straubing, Germany.
Dominik G GrimmTechnical University of Munich, Campus Straubing for Biotechnology and Sustainability, Bioinformatics, 94315 Straubing, Germany.ORCID https://orcid.org/0000-0003-2085-4591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein thermostability is important in many areas of biotechnology, including enzyme engineering and protein-hybrid optoelectronics. Ever-growing protein databases and information on stability at different temperatures allow the training of machine learning models to predict whether proteins are thermophilic.

Identifiers

PMID37829176
PMCPMC10566323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.